{"id":163,"date":"2010-07-14T15:40:58","date_gmt":"2010-07-14T06:40:58","guid":{"rendered":"http:\/\/www.cns.atr.jp\/"},"modified":"2012-07-23T09:34:51","modified_gmt":"2012-07-23T00:34:51","slug":"neuroinformatics-en","status":"publish","type":"page","link":"https:\/\/bicr.atr.jp\/en\/neuroinformatics-en\/","title":{"rendered":"Neuroinformatics"},"content":{"rendered":"<div>\n<h2>Systems Biology of Cerebellar Purkinje Cells<\/h2>\n<div><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/bicr.atr.jp\/neuroinfo\/tanaka\/TanakaNeuronModelStructure.gif\" alt=\"Ca2+-LTD model\" width=\"240\" height=\"180\" \/><\/div>\n<div>\u00a0<a href=\"https:\/\/bicr.atr.jp\/neuroinfo\/tanaka\/index.html\">Ca<sup>2+<\/sup> LTD model<\/a>This Ca<sup>2+<\/sup> model quantatively reproduces the relationship of caged-Ca<sup>2+<\/sup> photolysis and cerebellar LTD induction. Used in &#8216;Ca<sup>2+<\/sup> Requirements for Cerebellar Long-Term Synaptic Depression: Role for a Postsynaptic Leaky Integrator.&#8217; Tanaka et al., Neuron (2007) 54, 787-800.<\/div>\n<\/div>\n<div><img decoding=\"async\" src=\"https:\/\/bicr.atr.jp\/neuroinfo\/image\/LTDmodel_top.gif\" alt=\"Block diagram of signaling pathways for cerebellar LTD\" \/><\/div>\n<div><a href=\"https:\/\/bicr.atr.jp\/neuroinfo\/doi\/index.html\">Ca<sup>2+<\/sup> dynamics model<\/a>This Ca<sup>2+<\/sup> model detects the temporal order of synaptic inputs from parallel and climbing fibers. The model coherently explains varoius LTD experiments derived from different Ca<sup>2+<\/sup> dynamics in simulation results. Used in &#8216;Inositol 1,4,5-Trisphosphatate-Dependent Ca<sup>2+<\/sup> Therehosld Dynamics Detect Spike Timing in Cerebellar Purkinje Cells. &#8216; Doi et al., J Neurosci (2005) 25, 950-961.<\/div>\n<div><a href=\"https:\/\/bicr.atr.jp\/neuroinfo\/kuroda\/index.html\">Signaling cascade model<\/a>Used in &#8216;Exploration of signal transduction pathways in cerebellar long-term depression by kinetic simulation. &#8216; Kuroda et al. J Neurosci 21, 5693-702. The authors have revealed that AMPA receptor phosphorylation is regulated by the linear cascades of PKC in the initial phase and by the MAP kinase-mediated positive feedback loop pathway in the intermediate phase.<\/div>\n<div>\n<table border=\"0\">\n<tbody>\n<tr>\n<td>\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Neuro Imaging Data Archives<\/h2>\n<p><a href=\"https:\/\/bicr.atr.jp\/neuroinfo\/image\/NeuroinformaticsICON.gif\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/bicr.atr.jp\/neuroinfo\/image\/NeuroinformaticsICON.gif\" alt=\"Block diagram of signaling pathways for cerebellar LTD\" width=\"240\" height=\"180\" \/> <\/a><a href=\"https:\/\/bicr.atr.jp\/neuroinfo\/neo\/\">Data Archives<\/a><\/p>\n<div>\n<table border=\"0\">\n<tbody>\n<tr>\n<td>\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Neuro Imaging Data Analysis<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/bicr.atr.jp\/neuroinfo\/image\/VBMEG-intro.png\" alt=\"VBMEG-intro\" width=\"240\" height=\"180\" \/><a title=\"new vbmeg_en\" href=\"http:\/\/vbmeg.atr.jp\/?lang=en\" target=\"_blank\"> MEG\/EEG source estimation using MRI\/fMRI information<\/a><\/p>\n<div>\n<table border=\"0\">\n<tbody>\n<tr>\n<td>\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>multi color software<\/h2>\n<p><a href=\"https:\/\/bicr.atr.jp\/neuro\/image\/VBMEG-intro.png\">\u00a0<\/a><\/p>\n<p><a href=\"https:\/\/bicr.atr.jp\/multi_color\/index_j.html\"><img decoding=\"async\" class=\"alignleft\" style=\"border: black 2px solid;\" src=\"..\/..\/wp-content\/uploads\/multi-col-rnd-img\/rotate.php\" border=\"2\" alt=\"\" align=\"right\" \/><\/a><\/p>\n<table style=\"width: 11px; height: 195px;\" border=\"0\">\n<tbody>\n<tr>\n<td>\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><a href=\"https:\/\/bicr.atr.jp\/multi_color\/index_j.html\" target=\"_top\">This software is a MATLAB program <\/a>to overlay a number of resulting imaging data maps of the contrast on a single brain structure image. It is also possible to express the overlapped contrast maps into the Three Dimensions.<br \/>\nPlease contact us at the e-mail address below for futher information.<br \/>\nBut please be forewarned that we are not responsible to answer every question.<\/p>\n<\/div>\n<p><img decoding=\"async\" src=\"https:\/\/bicr.atr.jp\/wp-content\/uploads\/2010\/07\/adr.png\"><\/img><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Systems Biology of Cerebellar Purkinje Cells \u00a0Ca2+ LTD modelThis Ca2+ model quantatively reproduces the relationship of caged-Ca2+ photolysis and cerebellar LTD induction. Used in &#8216;Ca2+ Requirements for Cerebellar Long-Term Synaptic Depression: Role for a Postsynaptic Leaky Integrator.&#8217; Tanaka et al., Neuron (2007) 54, 787-800. Ca2+ dynamics modelThis Ca2+ model detects the temporal order of synaptic inputs from parallel and climbing fibers. The model coherently explains varoius LTD experiments derived from different Ca2+ dynamics in simulation results. Used in &#8216;Inositol 1,4,5-Trisphosphatate-Dependent Ca2+ Therehosld Dynamics Detect Spike Timing in Cerebellar Purkinje Cells. &#8216; Doi et al., J Neurosci (2005) 25, 950-961. Signaling cascade modelUsed in &#8216;Exploration of signal transduction pathways in cerebellar [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":8,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-163","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bicr.atr.jp\/en\/wp-json\/wp\/v2\/pages\/163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bicr.atr.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bicr.atr.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bicr.atr.jp\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/bicr.atr.jp\/en\/wp-json\/wp\/v2\/comments?post=163"}],"version-history":[{"count":17,"href":"https:\/\/bicr.atr.jp\/en\/wp-json\/wp\/v2\/pages\/163\/revisions"}],"predecessor-version":[{"id":1814,"href":"https:\/\/bicr.atr.jp\/en\/wp-json\/wp\/v2\/pages\/163\/revisions\/1814"}],"wp:attachment":[{"href":"https:\/\/bicr.atr.jp\/en\/wp-json\/wp\/v2\/media?parent=163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}