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xgraph /moregraphs/conc4 0 0 2.0001 0 200 0 simundump xplot /moregraphs/conc3/IP3Rec.Co 3 524288 \ "delete_plot.w ; edit_plot.D " seagreen 0 0 1 simundump xplot /moregraphs/conc3/IP3R-IP3.Co 3 524288 \ "delete_plot.w ; edit_plot.D " seagreen 0 0 1 simundump xplot /moregraphs/conc3/IP3R-open.Co 3 524288 \ "delete_plot.w ; edit_plot.D " green 0 0 1 simundump xplot /moregraphs/conc3/IP3R_inact.Co 3 524288 \ "delete_plot.w ; edit_plot.D " black 0 0 1 simundump xplot /moregraphs/conc4/MgGreen*.Co 3 524288 \ "delete_plot.w ; edit_plot.D " green 0 0 1 simundump xplot /moregraphs/conc4/CaStore.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xcoredraw /edit/draw 0 -349 157 4 248 simundump xtree /edit/draw/tree 0 \ /kinetics/#[],/kinetics/#[]/#[],/kinetics/#[]/#[]/#[][TYPE!=proto],/kinetics/#[]/#[]/#[][TYPE!=linkinfo]/##[] \ "edit_elm.D ; drag_from_edit.w " auto 0.6 simundump xtext /file/notes 0 1 xtextload /file/notes \ "This GENESIS/kinetikit scripts are for the simulation model of " \ "Doi T, Kuroda S, Michikawa T, Kawato M (2005) Inositol 1,4,5-Trisphosphate-Dependent Ca2+ Thereshold Dynamics Detect" \ "Spike Timing in Cerebellar Purkinje Cells. J Neurosci 25:950-961." addmsg /kinetics/IP3R/IP3R_bind_IP3 /kinetics/IP3R/IP3Rec REAC A B addmsg /kinetics/IP3R/IP3R_open /kinetics/IP3R/IP3Rec CONSERVE n nInit addmsg /kinetics/IP3R/IP3R-Ca /kinetics/IP3R/IP3Rec CONSERVE n nInit addmsg /kinetics/IP3R/IP3R_bind_Ca /kinetics/IP3R/IP3Rec REAC A B addmsg /kinetics/IP3R/IP3R-IP3 /kinetics/IP3R/IP3Rec CONSERVE n nInit addmsg /kinetics/IP3R/IP3R-2Ca /kinetics/IP3R/IP3Rec CONSERVE n nInit addmsg /kinetics/IP3R/IP3R-3Ca /kinetics/IP3R/IP3Rec CONSERVE n nInit addmsg /kinetics/IP3R/IP3R-4Ca /kinetics/IP3R/IP3Rec CONSERVE n nInit addmsg /kinetics/IP3R/bypass0_for_fig4E /kinetics/IP3R/IP3Rec REAC A B addmsg /kinetics/IP3R/IP3R_bind_IP3 /kinetics/IP3R/IP3R-IP3 REAC B A addmsg /kinetics/IP3R/IP3R-IP3_bind_Ca /kinetics/IP3R/IP3R-IP3 REAC A B addmsg /kinetics/IP3R/bypass_for_fig4C /kinetics/IP3R/IP3R-IP3 REAC A B addmsg /kinetics/CaReg/Ca2+ /kinetics/IP3R/Ca2+ INPUT addmsg /kinetics/IP3R/IP3R_bind_Ca /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R REAC A B addmsg /kinetics/IP3R/IP3R-IP3_bind_Ca /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R REAC A B addmsg /kinetics/IP3R/IP3R-Ca_bind_Ca /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R REAC A B addmsg /kinetics/IP3R/IP3R-2Ca_bind_Ca /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R REAC A B addmsg /kinetics/IP3R/IP3R-3Ca_bind_Ca /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R REAC A B addmsg /kinetics/CaReg/Ca2+/Ca2+ /kinetics/IP3R/Ca2+/Ca2+ LINK addmsg /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R /kinetics/IP3R/Ca2+/Ca2+/proto/Ca2+forIP3R MIRROR n addmsg /kinetics/IP3deg/IP3_prod /kinetics/IP3R/IP3 INPUT addmsg /kinetics/IP3R/IP3R_bind_IP3 /kinetics/IP3R/IP3/proto/IP3 REAC A B addmsg /kinetics/IP3deg/IP3_prod/IP3 /kinetics/IP3R/IP3/IP3_prod LINK addmsg /kinetics/IP3R/IP3/proto/IP3 /kinetics/IP3R/IP3/IP3_prod/proto/IP3 MIRROR n addmsg /kinetics/IP3R/IP3R/IP3R/proto/IP3Rmirror /kinetics/IP3R/IP3R/proto/IP3Rmirror MIRROR n addmsg /kinetics/CaReg/IP3R/IP3R/proto/IP3R /kinetics/IP3R/IP3R/IP3R/proto/IP3Rmirror MIRROR n addmsg /kinetics/IP3R/IP3R-IP3_bind_Ca /kinetics/IP3R/IP3R_open REAC B A addmsg /kinetics/IP3R/IP3R/proto/IP3Rmirror /kinetics/IP3R/IP3R_open MIRROR n addmsg /kinetics/IP3R/bypass_for_fig4C /kinetics/IP3R/IP3R_open REAC B A addmsg /kinetics/IP3R/IP3R-IP3 /kinetics/IP3R/IP3R-IP3_bind_Ca SUBSTRATE n addmsg /kinetics/IP3R/IP3R_open /kinetics/IP3R/IP3R-IP3_bind_Ca PRODUCT n addmsg /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R /kinetics/IP3R/IP3R-IP3_bind_Ca SUBSTRATE n addmsg /kinetics/IP3R/IP3Rec /kinetics/IP3R/IP3R_bind_IP3 SUBSTRATE n addmsg /kinetics/IP3R/IP3R-IP3 /kinetics/IP3R/IP3R_bind_IP3 PRODUCT n addmsg /kinetics/IP3R/IP3/proto/IP3 /kinetics/IP3R/IP3R_bind_IP3 SUBSTRATE n addmsg /kinetics/IP3R/IP3R_bind_Ca /kinetics/IP3R/IP3R-Ca REAC B A addmsg /kinetics/IP3R/IP3R-Ca_bind_Ca /kinetics/IP3R/IP3R-Ca REAC A B addmsg /kinetics/IP3R/bypass0_for_fig4E /kinetics/IP3R/IP3R-Ca REAC B A addmsg /kinetics/IP3R/bypass1_for_fig4E /kinetics/IP3R/IP3R-Ca REAC A B addmsg /kinetics/IP3R/IP3Rec /kinetics/IP3R/IP3R_bind_Ca SUBSTRATE n addmsg /kinetics/IP3R/IP3R-Ca /kinetics/IP3R/IP3R_bind_Ca PRODUCT n addmsg /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R /kinetics/IP3R/IP3R_bind_Ca SUBSTRATE n addmsg /kinetics/IP3R/IP3R-Ca /kinetics/IP3R/IP3R-Ca_bind_Ca SUBSTRATE n addmsg /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R /kinetics/IP3R/IP3R-Ca_bind_Ca SUBSTRATE n addmsg /kinetics/IP3R/IP3R-2Ca /kinetics/IP3R/IP3R-Ca_bind_Ca PRODUCT n addmsg /kinetics/IP3R/IP3R-Ca /kinetics/IP3R/IP3R_inact SUMTOTAL n nInit addmsg /kinetics/IP3R/IP3R-2Ca /kinetics/IP3R/IP3R_inact SUMTOTAL n nInit addmsg /kinetics/IP3R/IP3R-3Ca /kinetics/IP3R/IP3R_inact SUMTOTAL n nInit addmsg /kinetics/IP3R/IP3R-4Ca /kinetics/IP3R/IP3R_inact SUMTOTAL n nInit addmsg /kinetics/IP3R/IP3R-2Ca /kinetics/IP3R/IP3R-2Ca_bind_Ca SUBSTRATE n addmsg /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R /kinetics/IP3R/IP3R-2Ca_bind_Ca SUBSTRATE n addmsg /kinetics/IP3R/IP3R-3Ca /kinetics/IP3R/IP3R-2Ca_bind_Ca PRODUCT n addmsg /kinetics/IP3R/IP3R-3Ca /kinetics/IP3R/IP3R-3Ca_bind_Ca SUBSTRATE n addmsg /kinetics/IP3R/IP3R-4Ca /kinetics/IP3R/IP3R-3Ca_bind_Ca PRODUCT n addmsg /kinetics/IP3R/Ca2+/proto/Ca2+forIP3R /kinetics/IP3R/IP3R-3Ca_bind_Ca SUBSTRATE n addmsg /kinetics/IP3R/IP3R-2Ca_bind_Ca /kinetics/IP3R/IP3R-2Ca REAC A B addmsg /kinetics/IP3R/IP3R-Ca_bind_Ca /kinetics/IP3R/IP3R-2Ca REAC B A addmsg /kinetics/IP3R/bypass1_for_fig4E /kinetics/IP3R/IP3R-2Ca REAC B A addmsg /kinetics/IP3R/bypass2_for_fig4E /kinetics/IP3R/IP3R-2Ca REAC A B addmsg /kinetics/IP3R/IP3R-2Ca_bind_Ca /kinetics/IP3R/IP3R-3Ca REAC B A addmsg /kinetics/IP3R/IP3R-3Ca_bind_Ca /kinetics/IP3R/IP3R-3Ca REAC A B addmsg /kinetics/IP3R/bypass2_for_fig4E /kinetics/IP3R/IP3R-3Ca REAC B A addmsg /kinetics/IP3R/bypass3_for_fig4E /kinetics/IP3R/IP3R-3Ca REAC A B addmsg /kinetics/IP3R/IP3R-3Ca_bind_Ca /kinetics/IP3R/IP3R-4Ca REAC B A addmsg /kinetics/IP3R/bypass3_for_fig4E /kinetics/IP3R/IP3R-4Ca REAC B A addmsg /kinetics/IP3R/IP3R-IP3 /kinetics/IP3R/bypass_for_fig4C SUBSTRATE n addmsg /kinetics/IP3R/IP3R_open /kinetics/IP3R/bypass_for_fig4C PRODUCT n addmsg /kinetics/IP3R/basalCa_for_fig4C /kinetics/IP3R/bypass_for_fig4C SUBSTRATE n addmsg /kinetics/IP3R/bypass_for_fig4C /kinetics/IP3R/basalCa_for_fig4C REAC A B addmsg /kinetics/IP3R/bypass0_for_fig4E /kinetics/IP3R/basalCa_for_fig4F REAC A B addmsg /kinetics/IP3R/bypass1_for_fig4E /kinetics/IP3R/basalCa_for_fig4F REAC A B addmsg /kinetics/IP3R/bypass2_for_fig4E /kinetics/IP3R/basalCa_for_fig4F REAC A B addmsg /kinetics/IP3R/bypass3_for_fig4E /kinetics/IP3R/basalCa_for_fig4F REAC A B addmsg /kinetics/IP3R/IP3Rec /kinetics/IP3R/bypass0_for_fig4E SUBSTRATE n addmsg /kinetics/IP3R/basalCa_for_fig4F /kinetics/IP3R/bypass0_for_fig4E SUBSTRATE n addmsg /kinetics/IP3R/IP3R-Ca /kinetics/IP3R/bypass0_for_fig4E PRODUCT n addmsg /kinetics/IP3R/basalCa_for_fig4F /kinetics/IP3R/bypass1_for_fig4E SUBSTRATE n addmsg /kinetics/IP3R/IP3R-Ca /kinetics/IP3R/bypass1_for_fig4E SUBSTRATE n addmsg /kinetics/IP3R/IP3R-2Ca /kinetics/IP3R/bypass1_for_fig4E PRODUCT n addmsg /kinetics/IP3R/IP3R-2Ca /kinetics/IP3R/bypass2_for_fig4E SUBSTRATE n addmsg /kinetics/IP3R/basalCa_for_fig4F /kinetics/IP3R/bypass2_for_fig4E SUBSTRATE n addmsg /kinetics/IP3R/IP3R-3Ca /kinetics/IP3R/bypass2_for_fig4E PRODUCT n addmsg /kinetics/IP3R/IP3R-3Ca /kinetics/IP3R/bypass3_for_fig4E SUBSTRATE n addmsg /kinetics/IP3R/IP3R-4Ca /kinetics/IP3R/bypass3_for_fig4E PRODUCT n addmsg /kinetics/IP3R/basalCa_for_fig4F /kinetics/IP3R/bypass3_for_fig4E SUBSTRATE n addmsg /kinetics/mGluR/mGluR_bind_Gq /kinetics/mGluR/mGluR REAC A B addmsg /kinetics/mGluR/Glu_bind_mGluR /kinetics/mGluR/mGluR REAC A B addmsg /kinetics/mGluR/mGluR-Gq /kinetics/mGluR/mGluR CONSERVE n nInit addmsg /kinetics/mGluR/Glu-mGluR-Gq /kinetics/mGluR/mGluR CONSERVE n nInit addmsg /kinetics/mGluR/mGluR-Glu /kinetics/mGluR/mGluR CONSERVE n nInit addmsg /kinetics/mGluR/Glu_bind_mGluR-Gq /kinetics/mGluR/Glu REAC A B addmsg /kinetics/mGluR/Glu_bind_mGluR /kinetics/mGluR/Glu REAC A B addmsg /kinetics/mGluR/100Hz5Glu /kinetics/mGluR/Glu SLAVE output addmsg /kinetics/mGluR/Trimerize_Gq /kinetics/mGluR/Gbc REAC A B addmsg /kinetics/mGluR/Basal_ActGq /kinetics/mGluR/Gbc REAC B A addmsg /kinetics/mGluR/Activate_Gq /kinetics/mGluR/Gbc REAC B A addmsg /kinetics/mGluR/Glu_bind_mGluR /kinetics/mGluR/mGluR-Glu REAC B A addmsg /kinetics/mGluR/mGluR-Glu_bind_Gq /kinetics/mGluR/mGluR-Glu REAC A B addmsg /kinetics/mGluR/Activate_Gq /kinetics/mGluR/mGluR-Glu REAC B A addmsg /kinetics/CaReg/Ca2+PSD /kinetics/mGluR/Ca2+forPLC INPUT addmsg /kinetics/PLC/PLC-PIP2_bind_Ca /kinetics/mGluR/Ca2+forPLC/proto/Ca2+forPLC REAC A B addmsg /kinetics/PLC/PLC-PIP2-Gq_bind_Ca /kinetics/mGluR/Ca2+forPLC/proto/Ca2+forPLC REAC A B addmsg /kinetics/CaReg/Ca2+PSD/Ca2+forPLC /kinetics/mGluR/Ca2+forPLC/Ca2+PSD LINK addmsg /kinetics/mGluR/Ca2+forPLC/proto/Ca2+forPLC /kinetics/mGluR/Ca2+forPLC/Ca2+PSD/proto/Ca2+ MIRROR n addmsg /kinetics/mGluR/Inact_Gq /kinetics/mGluR/Ga-GDP REAC B A addmsg /kinetics/mGluR/Trimerize_Gq /kinetics/mGluR/Ga-GDP REAC A B addmsg /kinetics/PLC/inact_Gq_by_PLC-PIP2 /kinetics/mGluR/Ga-GDP REAC B A addmsg /kinetics/PLC/inact_Gq_by_PLC-PIP2-Ca /kinetics/mGluR/Ga-GDP REAC B A addmsg /kinetics/PLC/inact_Gq_by_PLC-Ca /kinetics/mGluR/Ga-GDP REAC B A addmsg /kinetics/mGluR/Trimerize_Gq /kinetics/mGluR/Gq-GDP REAC B A addmsg /kinetics/mGluR/Basal_ActGq /kinetics/mGluR/Gq-GDP REAC A B addmsg /kinetics/mGluR/mGluR_bind_Gq /kinetics/mGluR/Gq-GDP REAC A B addmsg /kinetics/mGluR/mGluR-Glu_bind_Gq /kinetics/mGluR/Gq-GDP REAC A B addmsg /kinetics/mGluR/mGluR-Gq /kinetics/mGluR/Gq-GDP CONSERVE n nInit addmsg /kinetics/mGluR/Glu-mGluR-Gq /kinetics/mGluR/Gq-GDP CONSERVE n nInit addmsg /kinetics/mGluR/Ga-GTP /kinetics/mGluR/Gq-GDP CONSERVE n nInit addmsg /kinetics/mGluR/Ga-GDP /kinetics/mGluR/Gq-GDP CONSERVE n nInit addmsg /kinetics/PLC/PLC-PIP2-Gq /kinetics/mGluR/Gq-GDP CONSERVE n nInit addmsg /kinetics/PLC/PLC-PIP2-Ca-Gq /kinetics/mGluR/Gq-GDP CONSERVE n nInit addmsg /kinetics/PLC/PLC-Ca-Gq /kinetics/mGluR/Gq-GDP CONSERVE n nInit addmsg /kinetics/mGluR/Basal_ActGq /kinetics/mGluR/Ga-GTP REAC B A addmsg /kinetics/mGluR/Inact_Gq /kinetics/mGluR/Ga-GTP REAC A B addmsg /kinetics/PLC/PLC-PIP2-Ca_bind_Gq /kinetics/mGluR/Ga-GTP REAC A B addmsg /kinetics/PLC/PLC-PIP2_bind_Gq /kinetics/mGluR/Ga-GTP REAC A B addmsg /kinetics/mGluR/Activate_Gq /kinetics/mGluR/Ga-GTP REAC B A addmsg /kinetics/PLC/PLC-Ca_bind_Gq /kinetics/mGluR/Ga-GTP REAC A B addmsg /kinetics/mGluR/mGluR_bind_Gq /kinetics/mGluR/mGluR-Gq REAC B A addmsg /kinetics/mGluR/Glu_bind_mGluR-Gq /kinetics/mGluR/mGluR-Gq REAC A B addmsg /kinetics/mGluR/Glu_bind_mGluR-Gq /kinetics/mGluR/Glu-mGluR-Gq REAC B A addmsg /kinetics/mGluR/mGluR-Glu_bind_Gq /kinetics/mGluR/Glu-mGluR-Gq REAC B A addmsg /kinetics/mGluR/Activate_Gq /kinetics/mGluR/Glu-mGluR-Gq REAC A B addmsg /kinetics/mGluR/Gq-GDP /kinetics/mGluR/mGluR_bind_Gq SUBSTRATE n addmsg /kinetics/mGluR/mGluR /kinetics/mGluR/mGluR_bind_Gq SUBSTRATE n addmsg /kinetics/mGluR/mGluR-Gq /kinetics/mGluR/mGluR_bind_Gq PRODUCT n addmsg /kinetics/mGluR/Glu /kinetics/mGluR/Glu_bind_mGluR-Gq SUBSTRATE n addmsg /kinetics/mGluR/mGluR-Gq /kinetics/mGluR/Glu_bind_mGluR-Gq SUBSTRATE n addmsg /kinetics/mGluR/Glu-mGluR-Gq /kinetics/mGluR/Glu_bind_mGluR-Gq PRODUCT n addmsg /kinetics/mGluR/Glu /kinetics/mGluR/Glu_bind_mGluR SUBSTRATE n addmsg /kinetics/mGluR/mGluR /kinetics/mGluR/Glu_bind_mGluR SUBSTRATE n addmsg /kinetics/mGluR/mGluR-Glu /kinetics/mGluR/Glu_bind_mGluR PRODUCT n addmsg /kinetics/mGluR/Gq-GDP /kinetics/mGluR/mGluR-Glu_bind_Gq SUBSTRATE n addmsg /kinetics/mGluR/mGluR-Glu /kinetics/mGluR/mGluR-Glu_bind_Gq SUBSTRATE n addmsg /kinetics/mGluR/Glu-mGluR-Gq /kinetics/mGluR/mGluR-Glu_bind_Gq PRODUCT n addmsg /kinetics/mGluR/Glu-mGluR-Gq /kinetics/mGluR/Activate_Gq SUBSTRATE n addmsg /kinetics/mGluR/Ga-GTP /kinetics/mGluR/Activate_Gq PRODUCT n addmsg /kinetics/mGluR/Gbc /kinetics/mGluR/Activate_Gq PRODUCT n addmsg /kinetics/mGluR/mGluR-Glu /kinetics/mGluR/Activate_Gq PRODUCT n addmsg /kinetics/mGluR/Gq-GDP /kinetics/mGluR/Basal_ActGq SUBSTRATE n addmsg /kinetics/mGluR/Gbc /kinetics/mGluR/Basal_ActGq PRODUCT n addmsg /kinetics/mGluR/Ga-GTP /kinetics/mGluR/Basal_ActGq PRODUCT n addmsg /kinetics/mGluR/Ga-GDP /kinetics/mGluR/Inact_Gq PRODUCT n addmsg /kinetics/mGluR/Ga-GTP /kinetics/mGluR/Inact_Gq SUBSTRATE n addmsg /kinetics/mGluR/Ga-GDP /kinetics/mGluR/Trimerize_Gq SUBSTRATE n addmsg /kinetics/mGluR/Gq-GDP /kinetics/mGluR/Trimerize_Gq PRODUCT n addmsg /kinetics/mGluR/Gbc /kinetics/mGluR/Trimerize_Gq SUBSTRATE n addmsg /kinetics/CaReg/Ca2+ /kinetics/Influx/Ca INPUT addmsg /kinetics/Influx/100Hz5PFCa-in /kinetics/Influx/Ca/proto/Ca2+ REAC B A addmsg /kinetics/Influx/CF-in /kinetics/Influx/Ca/proto/Ca2+ REAC B A addmsg /kinetics/CaReg/Ca2+/Ca[1] /kinetics/Influx/Ca/Ca2+ LINK addmsg /kinetics/Influx/Ca/proto/Ca2+ /kinetics/Influx/Ca/Ca2+/proto/Ca2+ MIRROR n addmsg /kinetics/Influx/100Hz5PFCa_pool /kinetics/Influx/100Hz5PFCa-in SUBSTRATE n addmsg /kinetics/Influx/Ca/proto/Ca2+ /kinetics/Influx/100Hz5PFCa-in PRODUCT n addmsg /kinetics/Influx/CF_pool /kinetics/Influx/CF-in SUBSTRATE n addmsg /kinetics/Influx/Ca/proto/Ca2+ /kinetics/Influx/CF-in PRODUCT n addmsg /kinetics/Influx/CF /kinetics/Influx/CF_pool SLAVE output addmsg /kinetics/Influx/CF-in /kinetics/Influx/CF_pool REAC A B addmsg /kinetics/Influx/100Hz5PFCa /kinetics/Influx/100Hz5PFCa_pool SLAVE output addmsg /kinetics/Influx/100Hz5PFCa-in /kinetics/Influx/100Hz5PFCa_pool REAC A B addmsg /kinetics/IP3deg/IP3_prod/IP3/proto/IP3_spine /kinetics/IP3deg/IP3_spine MIRROR n addmsg /kinetics/PLC/IP3_diff /kinetics/IP3deg/IP3_spine REAC B A addmsg /kinetics/IP3deg/IP3K-2Ca_bind_IP3 /kinetics/IP3deg/IP3_spine REAC A B addmsg /kinetics/IP3deg/IP5P_bind_IP3 /kinetics/IP3deg/IP3_spine REAC A B addmsg /kinetics/IP3deg/IP3K_bind_Ca /kinetics/IP3deg/Ca2+spine REAC A B addmsg /kinetics/IP3deg/IP3K_bind_Ca /kinetics/IP3deg/Ca2+spine REAC A B addmsg /kinetics/IP3deg/IP3K_deg_IP3 /kinetics/IP3deg/IP4 REAC B A addmsg /kinetics/IP3deg/IP5P_deg_IP3 /kinetics/IP3deg/IP2 REAC B A addmsg /kinetics/IP3R/IP3/IP3_prod/proto/IP3 /kinetics/IP3deg/IP3_prod/IP3/proto/IP3_spine MIRROR n addmsg /kinetics/CaReg/Ca2+ /kinetics/IP3deg/Ca2+for3-kin INPUT addmsg /kinetics/CaReg/Ca2+/Ca2+for3-kin /kinetics/IP3deg/Ca2+for3-kin/Ca2+ LINK addmsg /kinetics/IP3deg/Ca2+spine /kinetics/IP3deg/Ca2+for3-kin/Ca2+/proto/Ca2+spine MIRROR n addmsg /kinetics/IP3deg/IP5P_bind_IP3 /kinetics/IP3deg/IP3_5-phosphatase REAC A B addmsg /kinetics/IP3deg/IP5P_deg_IP3 /kinetics/IP3deg/IP3_5-phosphatase REAC B A addmsg /kinetics/IP3deg/IP5P-IP3 /kinetics/IP3deg/IP3_5-phosphatase CONSERVE n nInit addmsg /kinetics/IP3deg/IP3K-2Ca /kinetics/IP3deg/IP3_3-kinase CONSERVE n nInit addmsg /kinetics/IP3deg/IP3K-2Ca-IP3 /kinetics/IP3deg/IP3_3-kinase CONSERVE n nInit addmsg /kinetics/IP3deg/IP3K_bind_Ca /kinetics/IP3deg/IP3_3-kinase REAC A B addmsg /kinetics/IP3deg/IP3K-2Ca_bind_IP3 /kinetics/IP3deg/IP3K-2Ca REAC A B addmsg /kinetics/IP3deg/IP3K_deg_IP3 /kinetics/IP3deg/IP3K-2Ca REAC B A addmsg /kinetics/IP3deg/IP3K_bind_Ca /kinetics/IP3deg/IP3K-2Ca REAC B A addmsg /kinetics/IP3deg/IP3K-2Ca_bind_IP3 /kinetics/IP3deg/IP3K-2Ca-IP3 REAC B A addmsg /kinetics/IP3deg/IP3K_deg_IP3 /kinetics/IP3deg/IP3K-2Ca-IP3 REAC A B addmsg /kinetics/IP3deg/IP5P_bind_IP3 /kinetics/IP3deg/IP5P-IP3 REAC B A addmsg /kinetics/IP3deg/IP5P_deg_IP3 /kinetics/IP3deg/IP5P-IP3 REAC A B addmsg /kinetics/IP3deg/IP3K-2Ca /kinetics/IP3deg/IP3K-2Ca_bind_IP3 SUBSTRATE n addmsg /kinetics/IP3deg/IP3_spine /kinetics/IP3deg/IP3K-2Ca_bind_IP3 SUBSTRATE n addmsg /kinetics/IP3deg/IP3K-2Ca-IP3 /kinetics/IP3deg/IP3K-2Ca_bind_IP3 PRODUCT n addmsg /kinetics/IP3deg/IP3K-2Ca-IP3 /kinetics/IP3deg/IP3K_deg_IP3 SUBSTRATE n addmsg /kinetics/IP3deg/IP3K-2Ca /kinetics/IP3deg/IP3K_deg_IP3 PRODUCT n addmsg /kinetics/IP3deg/IP4 /kinetics/IP3deg/IP3K_deg_IP3 PRODUCT n addmsg /kinetics/IP3deg/IP3_5-phosphatase /kinetics/IP3deg/IP5P_bind_IP3 SUBSTRATE n addmsg /kinetics/IP3deg/IP3_spine /kinetics/IP3deg/IP5P_bind_IP3 SUBSTRATE n addmsg /kinetics/IP3deg/IP5P-IP3 /kinetics/IP3deg/IP5P_bind_IP3 PRODUCT n addmsg /kinetics/IP3deg/IP3_5-phosphatase /kinetics/IP3deg/IP5P_deg_IP3 PRODUCT n addmsg /kinetics/IP3deg/IP5P-IP3 /kinetics/IP3deg/IP5P_deg_IP3 SUBSTRATE n addmsg /kinetics/IP3deg/IP2 /kinetics/IP3deg/IP5P_deg_IP3 PRODUCT n addmsg /kinetics/IP3deg/IP3_3-kinase /kinetics/IP3deg/IP3K_bind_Ca SUBSTRATE n addmsg /kinetics/IP3deg/Ca2+spine /kinetics/IP3deg/IP3K_bind_Ca SUBSTRATE n addmsg /kinetics/IP3deg/IP3K-2Ca /kinetics/IP3deg/IP3K_bind_Ca PRODUCT n addmsg /kinetics/IP3deg/Ca2+spine /kinetics/IP3deg/IP3K_bind_Ca SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2_bind_Gq /kinetics/PLC/PLC-PIP2 REAC A B addmsg /kinetics/PLC/inact_Gq_by_PLC-PIP2 /kinetics/PLC/PLC-PIP2 REAC B A addmsg /kinetics/PLC/PLC-PIP2_bind_Ca /kinetics/PLC/PLC-PIP2 REAC A B addmsg /kinetics/PLC/PLC-PIP2-Gq /kinetics/PLC/PLC-PIP2 CONSERVE n nInit addmsg /kinetics/PLC/PLC-PIP2-Ca /kinetics/PLC/PLC-PIP2 CONSERVE n nInit addmsg /kinetics/PLC/PLC-PIP2-Ca-Gq /kinetics/PLC/PLC-PIP2 CONSERVE n nInit addmsg /kinetics/PLC/PLC-Ca /kinetics/PLC/PLC-PIP2 CONSERVE n nInit addmsg /kinetics/PLC/PLC-Ca-Gq /kinetics/PLC/PLC-PIP2 CONSERVE n nInit addmsg /kinetics/PLC/bypass0_for_fig4D /kinetics/PLC/PLC-PIP2 REAC A B addmsg /kinetics/PLC/PLC-PIP2 /kinetics/PLC/PLC-PIP2_bind_Gq SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Gq /kinetics/PLC/PLC-PIP2_bind_Gq PRODUCT n addmsg /kinetics/mGluR/Ga-GTP /kinetics/PLC/PLC-PIP2_bind_Gq SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2_bind_Gq /kinetics/PLC/PLC-PIP2-Gq REAC B A addmsg /kinetics/PLC/inact_Gq_by_PLC-PIP2 /kinetics/PLC/PLC-PIP2-Gq REAC A B addmsg /kinetics/PLC/PLC-PIP2-Gq_bind_Ca /kinetics/PLC/PLC-PIP2-Gq REAC A B addmsg /kinetics/PLC/bypass1_for_fig4D /kinetics/PLC/PLC-PIP2-Gq REAC A B addmsg /kinetics/PLC/PLC-PIP2 /kinetics/PLC/PLC-PIP2_bind_Ca SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Ca /kinetics/PLC/PLC-PIP2_bind_Ca PRODUCT n addmsg /kinetics/mGluR/Ca2+forPLC/proto/Ca2+forPLC /kinetics/PLC/PLC-PIP2_bind_Ca SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Ca_bind_Gq /kinetics/PLC/PLC-PIP2-Ca REAC A B addmsg /kinetics/PLC/inact_Gq_by_PLC-PIP2-Ca /kinetics/PLC/PLC-PIP2-Ca REAC B A addmsg /kinetics/PLC/PLC-PIP2_bind_Ca /kinetics/PLC/PLC-PIP2-Ca REAC B A addmsg /kinetics/PLC/IP3_prd_without_Gq /kinetics/PLC/PLC-PIP2-Ca REAC A B addmsg /kinetics/PLC/PLC-Ca_bind_PIP2 /kinetics/PLC/PLC-PIP2-Ca REAC B A addmsg /kinetics/PLC/bypass0_for_fig4D /kinetics/PLC/PLC-PIP2-Ca REAC B A addmsg /kinetics/PLC/PLC-PIP2-Gq /kinetics/PLC/PLC-PIP2-Gq_bind_Ca SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Ca-Gq /kinetics/PLC/PLC-PIP2-Gq_bind_Ca PRODUCT n addmsg /kinetics/mGluR/Ca2+forPLC/proto/Ca2+forPLC /kinetics/PLC/PLC-PIP2-Gq_bind_Ca SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Gq /kinetics/PLC/inact_Gq_by_PLC-PIP2 SUBSTRATE n addmsg /kinetics/mGluR/Ga-GDP /kinetics/PLC/inact_Gq_by_PLC-PIP2 PRODUCT n addmsg /kinetics/PLC/PLC-PIP2 /kinetics/PLC/inact_Gq_by_PLC-PIP2 PRODUCT n addmsg /kinetics/PLC/PLC-PIP2-Ca-Gq /kinetics/PLC/inact_Gq_by_PLC-PIP2-Ca SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Ca /kinetics/PLC/inact_Gq_by_PLC-PIP2-Ca PRODUCT n addmsg /kinetics/mGluR/Ga-GDP /kinetics/PLC/inact_Gq_by_PLC-PIP2-Ca PRODUCT n addmsg /kinetics/PLC/PLC-PIP2-Ca_bind_Gq /kinetics/PLC/PLC-PIP2-Ca-Gq REAC B A addmsg /kinetics/PLC/inact_Gq_by_PLC-PIP2-Ca /kinetics/PLC/PLC-PIP2-Ca-Gq REAC A B addmsg /kinetics/PLC/PLC-PIP2-Gq_bind_Ca /kinetics/PLC/PLC-PIP2-Ca-Gq REAC B A addmsg /kinetics/PLC/IP3_prd_with_Gq /kinetics/PLC/PLC-PIP2-Ca-Gq REAC A B addmsg /kinetics/PLC/PLC-Ca-Gq_bind_PIP2 /kinetics/PLC/PLC-PIP2-Ca-Gq REAC B A addmsg /kinetics/PLC/bypass1_for_fig4D /kinetics/PLC/PLC-PIP2-Ca-Gq REAC B A addmsg /kinetics/PLC/PLC-PIP2-Ca /kinetics/PLC/PLC-PIP2-Ca_bind_Gq SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Ca-Gq /kinetics/PLC/PLC-PIP2-Ca_bind_Gq PRODUCT n addmsg /kinetics/mGluR/Ga-GTP /kinetics/PLC/PLC-PIP2-Ca_bind_Gq SUBSTRATE n addmsg /kinetics/PLC/PIP2 /kinetics/PLC/PLC-Ca_bind_PIP2 SUBSTRATE n addmsg /kinetics/PLC/PLC-Ca /kinetics/PLC/PLC-Ca_bind_PIP2 SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Ca /kinetics/PLC/PLC-Ca_bind_PIP2 PRODUCT n addmsg /kinetics/PLC/PLC-Ca-Gq_bind_PIP2 /kinetics/PLC/PIP2 REAC A B addmsg /kinetics/PLC/PLC-Ca_bind_PIP2 /kinetics/PLC/PIP2 REAC A B addmsg /kinetics/PLC/PIP2 /kinetics/PLC/PLC-Ca-Gq_bind_PIP2 SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Ca-Gq /kinetics/PLC/PLC-Ca-Gq_bind_PIP2 PRODUCT n addmsg /kinetics/PLC/PLC-Ca-Gq /kinetics/PLC/PLC-Ca-Gq_bind_PIP2 SUBSTRATE n addmsg /kinetics/mGluR/Ga-GTP /kinetics/PLC/PLC-Ca_bind_Gq SUBSTRATE n addmsg /kinetics/PLC/PLC-Ca /kinetics/PLC/PLC-Ca_bind_Gq SUBSTRATE n addmsg /kinetics/PLC/PLC-Ca-Gq /kinetics/PLC/PLC-Ca_bind_Gq PRODUCT n addmsg /kinetics/PLC/PLC-Ca_bind_Gq /kinetics/PLC/PLC-Ca REAC A B addmsg /kinetics/PLC/inact_Gq_by_PLC-Ca /kinetics/PLC/PLC-Ca REAC B A addmsg /kinetics/PLC/IP3_prd_without_Gq /kinetics/PLC/PLC-Ca REAC B A addmsg /kinetics/PLC/PLC-Ca_bind_PIP2 /kinetics/PLC/PLC-Ca REAC A B addmsg /kinetics/PLC/inact_Gq_by_PLC-Ca /kinetics/PLC/PLC-Ca-Gq REAC A B addmsg /kinetics/PLC/PLC-Ca_bind_Gq /kinetics/PLC/PLC-Ca-Gq REAC B A addmsg /kinetics/PLC/IP3_prd_with_Gq /kinetics/PLC/PLC-Ca-Gq REAC B A addmsg /kinetics/PLC/PLC-Ca-Gq_bind_PIP2 /kinetics/PLC/PLC-Ca-Gq REAC A B addmsg /kinetics/PLC/IP3_diff /kinetics/PLC/IP3_PSD REAC A B addmsg /kinetics/PLC/IP3_prd_with_Gq /kinetics/PLC/IP3_PSD REAC B A addmsg /kinetics/PLC/IP3_prd_without_Gq /kinetics/PLC/IP3_PSD REAC B A addmsg /kinetics/PLC/IP3_prd_with_Gq /kinetics/PLC/DAG REAC B A addmsg /kinetics/PLC/IP3_prd_without_Gq /kinetics/PLC/DAG REAC B A addmsg /kinetics/PLC/DAG /kinetics/PLC/IP3_prd_without_Gq PRODUCT n addmsg /kinetics/PLC/IP3_PSD /kinetics/PLC/IP3_prd_without_Gq PRODUCT n addmsg /kinetics/PLC/PLC-PIP2-Ca /kinetics/PLC/IP3_prd_without_Gq SUBSTRATE n addmsg /kinetics/PLC/PLC-Ca /kinetics/PLC/IP3_prd_without_Gq PRODUCT n addmsg /kinetics/PLC/DAG /kinetics/PLC/IP3_prd_with_Gq PRODUCT n addmsg /kinetics/PLC/IP3_PSD /kinetics/PLC/IP3_prd_with_Gq PRODUCT n addmsg /kinetics/PLC/PLC-Ca-Gq /kinetics/PLC/IP3_prd_with_Gq PRODUCT n addmsg /kinetics/PLC/PLC-PIP2-Ca-Gq /kinetics/PLC/IP3_prd_with_Gq SUBSTRATE n addmsg /kinetics/PLC/PLC-Ca-Gq /kinetics/PLC/inact_Gq_by_PLC-Ca SUBSTRATE n addmsg /kinetics/mGluR/Ga-GDP /kinetics/PLC/inact_Gq_by_PLC-Ca PRODUCT n addmsg /kinetics/PLC/PLC-Ca /kinetics/PLC/inact_Gq_by_PLC-Ca PRODUCT n addmsg /kinetics/PLC/IP3_PSD /kinetics/PLC/IP3_diff SUBSTRATE n addmsg /kinetics/IP3deg/IP3_spine /kinetics/PLC/IP3_diff PRODUCT n addmsg /kinetics/PLC/bypass0_for_fig4D /kinetics/PLC/basalCa_for_fig4D REAC A B addmsg /kinetics/PLC/bypass1_for_fig4D /kinetics/PLC/basalCa_for_fig4D REAC A B addmsg /kinetics/PLC/basalCa_for_fig4D /kinetics/PLC/bypass0_for_fig4D SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2 /kinetics/PLC/bypass0_for_fig4D SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Ca /kinetics/PLC/bypass0_for_fig4D PRODUCT n addmsg /kinetics/PLC/PLC-PIP2-Gq /kinetics/PLC/bypass1_for_fig4D SUBSTRATE n addmsg /kinetics/PLC/PLC-PIP2-Ca-Gq /kinetics/PLC/bypass1_for_fig4D PRODUCT n addmsg /kinetics/PLC/basalCa_for_fig4D /kinetics/PLC/bypass1_for_fig4D SUBSTRATE n addmsg /kinetics/CaReg/Ca_Leak_from_ext/Ca_Leak_chan_from_ext /kinetics/CaReg/Ca2+/proto/CaSpine REAC B A addmsg /kinetics/CaReg/IP3R/proto/IP3R/IP3R_Ca_channel /kinetics/CaReg/Ca2+/proto/CaSpine REAC B A addmsg /kinetics/CaReg/Ca_diff /kinetics/CaReg/Ca2+/proto/CaSpine REAC A B addmsg /kinetics/CaReg/Ca2+/Ca2+/proto/Ca /kinetics/CaReg/Ca2+/proto/CaSpine MIRROR n addmsg /kinetics/CaReg/Ca2+/Ca2+for3-kin/proto/Ca /kinetics/CaReg/Ca2+/proto/CaSpine MIRROR n addmsg /kinetics/CaReg/Ca2+/Ca/proto/Ca /kinetics/CaReg/Ca2+/proto/CaSpine MIRROR n addmsg /kinetics/CaReg/Ca2+/Ca[1]/proto/Ca /kinetics/CaReg/Ca2+/proto/CaSpine MIRROR n addmsg /kinetics/CaReg/SERCA_bind_2Ca /kinetics/CaReg/Ca2+/proto/CaSpine REAC A B addmsg /kinetics/CaReg/SERCA_bind_2Ca /kinetics/CaReg/Ca2+/proto/CaSpine REAC A B addmsg /kinetics/CaReg/PMCA_bind_Ca /kinetics/CaReg/Ca2+/proto/CaSpine REAC A B addmsg /kinetics/CaReg/NCX_bind_2Ca /kinetics/CaReg/Ca2+/proto/CaSpine REAC A B addmsg /kinetics/CaReg/NCX_bind_2Ca /kinetics/CaReg/Ca2+/proto/CaSpine REAC A B addmsg /kinetics/CaReg/Ca_Leak_from_ER/Ca_Leak_chan_from_ER /kinetics/CaReg/Ca2+/proto/CaSpine REAC B A addmsg /kinetics/IP3R/Ca2+/Ca2+/proto/Ca2+forIP3R /kinetics/CaReg/Ca2+/Ca2+/proto/Ca MIRROR n addmsg /kinetics/IP3deg/Ca2+for3-kin/Ca2+/proto/Ca2+spine /kinetics/CaReg/Ca2+/Ca2+for3-kin/proto/Ca MIRROR n addmsg /kinetics/CaBuf/Ca/Ca2+/proto/Ca2+ /kinetics/CaReg/Ca2+/Ca/proto/Ca MIRROR n addmsg /kinetics/Influx/Ca/Ca2+/proto/Ca2+ /kinetics/CaReg/Ca2+/Ca[1]/proto/Ca MIRROR n addmsg /kinetics/IP3R/IP3R /kinetics/CaReg/IP3R INPUT addmsg /kinetics/CaReg/IP3R/proto/IP3R /kinetics/CaReg/IP3R/proto/IP3R/IP3R_Ca_channel NUMCHAN n addmsg /kinetics/CaReg/CaStore /kinetics/CaReg/IP3R/proto/IP3R/IP3R_Ca_channel SUBSTRATE n vol addmsg /kinetics/CaReg/Ca2+/proto/CaSpine /kinetics/CaReg/IP3R/proto/IP3R/IP3R_Ca_channel PRODUCT n vol addmsg /kinetics/IP3R/IP3R/IP3R /kinetics/CaReg/IP3R/IP3R LINK addmsg /kinetics/CaReg/IP3R/proto/IP3R /kinetics/CaReg/IP3R/IP3R/proto/IP3R MIRROR n addmsg /kinetics/CaReg/Ca2+PSD/proto/Ca2+PSD /kinetics/CaReg/Ca_diff PRODUCT n addmsg /kinetics/CaReg/Ca2+/proto/CaSpine /kinetics/CaReg/Ca_diff SUBSTRATE n addmsg /kinetics/CaReg/Ca_diff /kinetics/CaReg/Ca2+PSD/proto/Ca2+PSD REAC B A addmsg /kinetics/CaReg/Ca2+PSD/Ca2+forPLC/proto/Ca2+PSD /kinetics/CaReg/Ca2+PSD/proto/Ca2+PSD MIRROR n addmsg /kinetics/mGluR/Ca2+forPLC/Ca2+PSD/proto/Ca2+ /kinetics/CaReg/Ca2+PSD/Ca2+forPLC/proto/Ca2+PSD MIRROR n addmsg /kinetics/CaReg/SERCA_bind_2Ca /kinetics/CaReg/SERCA REAC A B addmsg /kinetics/CaReg/SERCA_uptake /kinetics/CaReg/SERCA REAC B A addmsg /kinetics/CaReg/SERCA-2Ca /kinetics/CaReg/SERCA CONSERVE n nInit addmsg /kinetics/CaReg/PMCA_bind_Ca /kinetics/CaReg/PMCA REAC A B addmsg /kinetics/CaReg/PMCA_uptake /kinetics/CaReg/PMCA REAC B A addmsg /kinetics/CaReg/PMCA-Ca /kinetics/CaReg/PMCA CONSERVE n nInit addmsg /kinetics/CaReg/NCX_bind_2Ca /kinetics/CaReg/NCX REAC A B addmsg /kinetics/CaReg/NCX_uptake /kinetics/CaReg/NCX REAC B A addmsg /kinetics/CaReg/NCX-2Ca /kinetics/CaReg/NCX CONSERVE n nInit addmsg /kinetics/CaReg/CaStore_Dif /kinetics/CaReg/Castore_dend REAC B A addmsg /kinetics/CaReg/Ca_bind_calreticulin /kinetics/CaReg/calreticulin REAC A B addmsg /kinetics/CaReg/calreticulin-Ca /kinetics/CaReg/calreticulin CONSERVE n nInit addmsg /kinetics/CaReg/Ca_bind_calreticulin /kinetics/CaReg/calreticulin-Ca REAC B A addmsg /kinetics/CaReg/IP3R/proto/IP3R/IP3R_Ca_channel /kinetics/CaReg/CaStore REAC A B addmsg /kinetics/CaReg/Ca_bind_calreticulin /kinetics/CaReg/CaStore REAC A B addmsg /kinetics/CaReg/CaStore_Dif /kinetics/CaReg/CaStore REAC A B addmsg /kinetics/CaReg/SERCA_uptake /kinetics/CaReg/CaStore REAC B A addmsg /kinetics/CaReg/SERCA_uptake /kinetics/CaReg/CaStore REAC B A addmsg /kinetics/CaReg/Ca_Leak_from_ER/Ca_Leak_chan_from_ER /kinetics/CaReg/CaStore REAC A B addmsg /kinetics/CaReg/SERCA_bind_2Ca /kinetics/CaReg/SERCA-2Ca REAC B A addmsg /kinetics/CaReg/SERCA_uptake /kinetics/CaReg/SERCA-2Ca REAC A B addmsg /kinetics/CaReg/PMCA_bind_Ca /kinetics/CaReg/PMCA-Ca REAC B A addmsg /kinetics/CaReg/PMCA_uptake /kinetics/CaReg/PMCA-Ca REAC A B addmsg /kinetics/CaReg/NCX_bind_2Ca /kinetics/CaReg/NCX-2Ca REAC B A addmsg /kinetics/CaReg/NCX_uptake /kinetics/CaReg/NCX-2Ca REAC A B addmsg /kinetics/CaReg/SERCA-2Ca /kinetics/CaReg/SERCA_uptake SUBSTRATE n addmsg /kinetics/CaReg/SERCA /kinetics/CaReg/SERCA_uptake PRODUCT n addmsg /kinetics/CaReg/CaStore /kinetics/CaReg/SERCA_uptake PRODUCT n addmsg /kinetics/CaReg/CaStore /kinetics/CaReg/SERCA_uptake PRODUCT n addmsg /kinetics/CaReg/Ca2+/proto/CaSpine /kinetics/CaReg/NCX_bind_2Ca SUBSTRATE n addmsg /kinetics/CaReg/NCX /kinetics/CaReg/NCX_bind_2Ca SUBSTRATE n addmsg /kinetics/CaReg/NCX-2Ca /kinetics/CaReg/NCX_bind_2Ca PRODUCT n addmsg /kinetics/CaReg/Ca2+/proto/CaSpine /kinetics/CaReg/NCX_bind_2Ca SUBSTRATE n addmsg /kinetics/CaReg/Ca2+/proto/CaSpine /kinetics/CaReg/PMCA_bind_Ca SUBSTRATE n addmsg /kinetics/CaReg/PMCA /kinetics/CaReg/PMCA_bind_Ca SUBSTRATE n addmsg /kinetics/CaReg/PMCA-Ca /kinetics/CaReg/PMCA_bind_Ca PRODUCT n addmsg /kinetics/CaReg/calreticulin /kinetics/CaReg/Ca_bind_calreticulin SUBSTRATE n addmsg /kinetics/CaReg/CaStore /kinetics/CaReg/Ca_bind_calreticulin SUBSTRATE n addmsg /kinetics/CaReg/calreticulin-Ca /kinetics/CaReg/Ca_bind_calreticulin PRODUCT n addmsg /kinetics/CaReg/CaStore /kinetics/CaReg/CaStore_Dif SUBSTRATE n addmsg /kinetics/CaReg/Castore_dend /kinetics/CaReg/CaStore_Dif PRODUCT n addmsg /kinetics/CaReg/SERCA /kinetics/CaReg/SERCA_bind_2Ca SUBSTRATE n addmsg /kinetics/CaReg/SERCA-2Ca /kinetics/CaReg/SERCA_bind_2Ca PRODUCT n addmsg /kinetics/CaReg/Ca2+/proto/CaSpine /kinetics/CaReg/SERCA_bind_2Ca SUBSTRATE n addmsg /kinetics/CaReg/Ca2+/proto/CaSpine /kinetics/CaReg/SERCA_bind_2Ca SUBSTRATE n addmsg /kinetics/CaReg/Ca_Leak_from_ER /kinetics/CaReg/Ca_Leak_from_ER/Ca_Leak_chan_from_ER NUMCHAN n addmsg /kinetics/CaReg/CaStore /kinetics/CaReg/Ca_Leak_from_ER/Ca_Leak_chan_from_ER SUBSTRATE n vol addmsg /kinetics/CaReg/Ca2+/proto/CaSpine /kinetics/CaReg/Ca_Leak_from_ER/Ca_Leak_chan_from_ER PRODUCT n vol addmsg /kinetics/CaReg/PMCA-Ca /kinetics/CaReg/PMCA_uptake SUBSTRATE n addmsg /kinetics/CaReg/Ca_ext /kinetics/CaReg/PMCA_uptake PRODUCT n addmsg /kinetics/CaReg/PMCA /kinetics/CaReg/PMCA_uptake PRODUCT n addmsg /kinetics/CaReg/NCX-2Ca /kinetics/CaReg/NCX_uptake SUBSTRATE n addmsg /kinetics/CaReg/NCX /kinetics/CaReg/NCX_uptake PRODUCT n addmsg /kinetics/CaReg/Ca_ext /kinetics/CaReg/NCX_uptake PRODUCT n addmsg /kinetics/CaReg/Ca_ext /kinetics/CaReg/NCX_uptake PRODUCT n addmsg /kinetics/CaReg/Ca_Leak_from_ext/Ca_Leak_chan_from_ext /kinetics/CaReg/Ca_ext REAC A B addmsg /kinetics/CaReg/PMCA_uptake /kinetics/CaReg/Ca_ext REAC B A addmsg /kinetics/CaReg/NCX_uptake /kinetics/CaReg/Ca_ext REAC B A addmsg /kinetics/CaReg/NCX_uptake /kinetics/CaReg/Ca_ext REAC B A addmsg /kinetics/CaReg/Ca_Leak_from_ext /kinetics/CaReg/Ca_Leak_from_ext/Ca_Leak_chan_from_ext NUMCHAN n addmsg /kinetics/CaReg/Ca_ext /kinetics/CaReg/Ca_Leak_from_ext/Ca_Leak_chan_from_ext SUBSTRATE n vol addmsg /kinetics/CaReg/Ca2+/proto/CaSpine /kinetics/CaReg/Ca_Leak_from_ext/Ca_Leak_chan_from_ext PRODUCT n vol addmsg /kinetics/CaBuf/CB_bind_2Ca /kinetics/CaBuf/Calbindin-D28k REAC A B addmsg /kinetics/CaBuf/CB-2Ca /kinetics/CaBuf/Calbindin-D28k CONSERVE n nInit addmsg /kinetics/CaReg/Ca2+ /kinetics/CaBuf/Ca INPUT addmsg /kinetics/CaBuf/Ca_bind_MgGreen /kinetics/CaBuf/Ca/proto/Ca2+ REAC A B addmsg /kinetics/CaBuf/CB_bind_2Ca /kinetics/CaBuf/Ca/proto/Ca2+ REAC A B addmsg /kinetics/CaBuf/CB_bind_2Ca /kinetics/CaBuf/Ca/proto/Ca2+ REAC A B addmsg /kinetics/CaBuf/PV_bind_Ca /kinetics/CaBuf/Ca/proto/Ca2+ REAC A B addmsg /kinetics/CaBuf/LAB_bind_Ca /kinetics/CaBuf/Ca/proto/Ca2+ REAC A B addmsg /kinetics/CaBuf/LAB2_bind_2Ca /kinetics/CaBuf/Ca/proto/Ca2+ REAC A B addmsg /kinetics/CaBuf/LAB2_bind_2Ca /kinetics/CaBuf/Ca/proto/Ca2+ REAC A B addmsg /kinetics/CaReg/Ca2+/Ca /kinetics/CaBuf/Ca/Ca2+ LINK addmsg /kinetics/CaBuf/Ca/proto/Ca2+ /kinetics/CaBuf/Ca/Ca2+/proto/Ca2+ MIRROR n addmsg /kinetics/CaBuf/PV_bind_Ca /kinetics/CaBuf/parvalbumin REAC A B addmsg /kinetics/CaBuf/PV-Ca /kinetics/CaBuf/parvalbumin CONSERVE n nInit addmsg /kinetics/CaBuf/PV_bind_Ca /kinetics/CaBuf/PV-Ca REAC B A addmsg /kinetics/CaBuf/LAB_bind_Ca /kinetics/CaBuf/LowAffBuf REAC A B addmsg /kinetics/CaBuf/LAB-Ca /kinetics/CaBuf/LowAffBuf CONSERVE n nInit addmsg /kinetics/CaBuf/LAB2-2Ca /kinetics/CaBuf/LowAffBuf2 CONSERVE n nInit addmsg /kinetics/CaBuf/LAB2_bind_2Ca /kinetics/CaBuf/LowAffBuf2 REAC A B addmsg /kinetics/CaBuf/Ca_bind_MgGreen /kinetics/CaBuf/MgGreen REAC A B addmsg /kinetics/CaBuf/MgGreen* /kinetics/CaBuf/MgGreen CONSERVE n nInit addmsg /kinetics/CaBuf/MgGreen /kinetics/CaBuf/Ca_bind_MgGreen SUBSTRATE n addmsg /kinetics/CaBuf/MgGreen* /kinetics/CaBuf/Ca_bind_MgGreen PRODUCT n addmsg /kinetics/CaBuf/Ca/proto/Ca2+ /kinetics/CaBuf/Ca_bind_MgGreen SUBSTRATE n addmsg /kinetics/CaBuf/parvalbumin /kinetics/CaBuf/PV_bind_Ca SUBSTRATE n addmsg /kinetics/CaBuf/PV-Ca /kinetics/CaBuf/PV_bind_Ca PRODUCT n addmsg /kinetics/CaBuf/Ca/proto/Ca2+ /kinetics/CaBuf/PV_bind_Ca SUBSTRATE n addmsg /kinetics/CaBuf/Calbindin-D28k /kinetics/CaBuf/CB_bind_2Ca SUBSTRATE n addmsg /kinetics/CaBuf/CB-2Ca /kinetics/CaBuf/CB_bind_2Ca PRODUCT n addmsg /kinetics/CaBuf/Ca/proto/Ca2+ /kinetics/CaBuf/CB_bind_2Ca SUBSTRATE n addmsg /kinetics/CaBuf/Ca/proto/Ca2+ /kinetics/CaBuf/CB_bind_2Ca SUBSTRATE n addmsg /kinetics/CaBuf/CB_bind_2Ca /kinetics/CaBuf/CB-2Ca REAC B A addmsg /kinetics/CaBuf/LAB_bind_Ca /kinetics/CaBuf/LAB-Ca REAC B A addmsg /kinetics/CaBuf/LowAffBuf /kinetics/CaBuf/LAB_bind_Ca SUBSTRATE n addmsg /kinetics/CaBuf/LAB-Ca /kinetics/CaBuf/LAB_bind_Ca PRODUCT n addmsg /kinetics/CaBuf/Ca/proto/Ca2+ /kinetics/CaBuf/LAB_bind_Ca SUBSTRATE n addmsg /kinetics/CaBuf/LowAffBuf2 /kinetics/CaBuf/LAB2_bind_2Ca SUBSTRATE n addmsg /kinetics/CaBuf/LAB2-2Ca /kinetics/CaBuf/LAB2_bind_2Ca PRODUCT n addmsg /kinetics/CaBuf/Ca/proto/Ca2+ /kinetics/CaBuf/LAB2_bind_2Ca SUBSTRATE n addmsg /kinetics/CaBuf/Ca/proto/Ca2+ /kinetics/CaBuf/LAB2_bind_2Ca SUBSTRATE n addmsg /kinetics/CaBuf/LAB2_bind_2Ca /kinetics/CaBuf/LAB2-2Ca REAC B A addmsg /kinetics/CaBuf/Ca_bind_MgGreen /kinetics/CaBuf/MgGreen* REAC B A addmsg /kinetics/mGluR/Glu /graphs/conc1/Glu.Co PLOT Co *Glu.Co *green addmsg /kinetics/mGluR/Glu-mGluR-Gq /graphs/conc1/mGluR-GluGq.Co PLOT Co *mGluR-GluGq.Co *orange addmsg /kinetics/IP3deg/IP3_spine /graphs/conc1/IP3_spine.Co PLOT Co *IP3_spine.Co *blue addmsg /kinetics/CaReg/Ca2+/proto/CaSpine /graphs/conc2/Ca.Co PLOT Co *Ca.Co *red addmsg /kinetics/CaReg/Ca2+PSD/proto/Ca2+PSD /graphs/conc2/Ca2+PSD.Co PLOT Co *Ca2+PSD.Co *orange addmsg /kinetics/IP3R/IP3Rec /moregraphs/conc3/IP3Rec.Co PLOT Co *IP3Rec.Co *seagreen addmsg /kinetics/IP3R/IP3R-IP3 /moregraphs/conc3/IP3R-IP3.Co PLOT Co *IP3R-IP3.Co *seagreen addmsg /kinetics/IP3R/IP3R_open /moregraphs/conc3/IP3R-open.Co PLOT Co *IP3R-open.Co *green addmsg /kinetics/IP3R/IP3R_inact /moregraphs/conc3/IP3R_inact.Co PLOT Co *IP3R_inact.Co *black addmsg /kinetics/CaBuf/MgGreen* /moregraphs/conc4/MgGreen*.Co PLOT Co *MgGreen*.Co *green addmsg /kinetics/CaReg/CaStore /moregraphs/conc4/CaStore.Co PLOT Co *CaStore.Co *red enddump // End of dump call /kinetics/IP3R/notes LOAD \ "We developed a novel kinetic model of IP3Rs based on a " \ "conceptual model in Adkins and Taylor (1999) Curr Biol " \ "9:1115-1118. IP3R opening requires sequential binding of IP3 " \ "and Ca2+. IP3 binding serves to switch the Ca2+ sensitivity " \ "of IP3Rs by causing inhibitory sites to be masked and a " \ "stimulatory site to be exposed." call /kinetics/IP3R/IP3Rec/notes LOAD \ "IP3R type 1 is highly expressed in Purkinje cells. " \ "We counted 16 immunogold spots in the figure of the PF spine " \ "slice in Otsu et al. (1990) Cell Struct Function 15:163-173. " \ "Since the slice has 1/4 thickness of a spine and IP3Rs are " \ "homotetramers, the number of IP3Rs in a PF spine was " \ "estimated to be 16 (= 16 /(1/4) /4). " call /kinetics/IP3R/IP3R-IP3/notes LOAD \ "IP3-bound state of IP3Rs. " \ "In our IP3R kinetics model, IP3 binding to IP3Rs allows " \ "activation of the IP3Rs by Ca2+." call /kinetics/IP3R/IP3R_open/notes LOAD \ "Open state of IP3Rs." call /kinetics/IP3R/IP3R-IP3_bind_Ca/notes LOAD \ "Ca2+ directly binds to IP3Rs for activation. From a bell- " \ "shaped Ca2+-dependency of IP3Rs (Bezprozvanny and Ehric " \ "(1994) J Gen Physiol 104:821-856; Fujiwara et al. (2001) " \ "Neuroreport 12:2647-2651), we obtained Kd = 0.25 uM. The " \ "reaction must be faster than Ca2+-dependent IP3R inactivation " \ "for Ca2+ positive feedback." call /kinetics/IP3R/IP3R_bind_IP3/notes LOAD \ "From measurement of Ca2+ depletion of the ER stores, the " \ "affinity of IP3Rs for IP3 in Purkinje cells is much lower " \ "(Kd = 25.8 uM) than in vitro (Fujiwara et al. (2001) " \ "Neuroreport 12:2647-2651). The low affinity is consistent " \ "with the fact that Ca2+ response to IP3 uncaging in Purkinje " \ "cells require strong photostimulus ([IP3] > 10 uM) for " \ "(Khodakhah and Ogden (1993) PNAS 90:4976-4980; Finch and " \ "Augustine (1998) Nature 396:753-756). Thus, we used Kd of " \ "25.8 uM in the simulation." call /kinetics/IP3R/IP3R-Ca/notes LOAD \ "Inactivation state of IP3Rs, bound to one Ca2+ ion." call /kinetics/IP3R/IP3R_bind_Ca/notes LOAD \ "IP3Rs are completely inactivated at high concentrations of " \ "[Ca2+]i (< 10 uM). In our kinetic model, an IP3R has four " \ "Ca2+ inactivation sites. This sequential Ca2+ binding " \ "reaction was assumed to be positively cooperative. In other " \ "words, Ca2+ ions bind a subunit easier as more Ca2+ binds to " \ "IP3Rs. How to estimate these parameters is written in Ca2+-" \ "dependent IP3R inactivation in the Material and Methods." call /kinetics/IP3R/IP3R-Ca_bind_Ca/notes LOAD \ "IP3Rs are completely inactivated at high concentrations of " \ "[Ca2+]i (< 10 uM). In our kinetic model, an IP3R has four " \ "Ca2+ inactivation sites. This sequential Ca2+ binding " \ "reaction was assumed to be positively cooperative. In other " \ "words, Ca2+ ions bind a subunit easier as more Ca2+ binds to " \ "IP3Rs. How to estimate these parameters is written in Ca2+-" \ "dependent IP3R inactivation in the Material and Methods." call /kinetics/IP3R/IP3R_inact/notes LOAD \ "The sum of inactivation states of IP3Rs by Ca binding." call /kinetics/IP3R/IP3R-2Ca_bind_Ca/notes LOAD \ "IP3Rs are completely inactivated at high concentrations of " \ "[Ca2+]i (< 10 uM). In our kinetic model, an IP3R has four " \ "Ca2+ inactivation sites. This sequential Ca2+ binding " \ "reaction was assumed to be positively cooperative. In other " \ "words, Ca2+ ions bind a subunit easier as more Ca2+ binds to " \ "IP3Rs. How to estimate these parameters is written in Ca2+-" \ "dependent IP3R inactivation in the Material and Methods." call /kinetics/IP3R/IP3R-3Ca_bind_Ca/notes LOAD \ "IP3Rs are completely inactivated at high concentrations of " \ "[Ca2+]i (< 10 uM). In our kinetic model, an IP3R has four " \ "Ca2+ inactivation sites. This sequential Ca2+ binding " \ "reaction was assumed to be positively cooperative. In other " \ "words, Ca2+ ions bind a subunit easier as more Ca2+ binds to " \ "IP3Rs. How to estimate these parameters is written in Ca2+-" \ "dependent IP3R inactivation in the Material and Methods." call /kinetics/IP3R/IP3R-2Ca/notes LOAD \ "Inactivation state of IP3Rs, bound to two Ca2+ ions." call /kinetics/IP3R/IP3R-3Ca/notes LOAD \ "Inactivation state of IP3Rs, bound to three Ca2+ ions." call /kinetics/IP3R/IP3R-4Ca/notes LOAD \ "Inactivation state of IP3Rs, bound to four Ca2+ ions." call /kinetics/IP3R/bypass_for_fig4C/notes LOAD \ "This bypass is used for pathway deletion in Fig.4C." \ "" call /kinetics/IP3R/basalCa_for_fig4C/notes LOAD \ "Basal [Ca2+]i = 0.06 uM." \ "" call /kinetics/IP3R/basalCa_for_fig4F/notes LOAD \ "Basal [Ca2+]i = 0.06 uM." \ "" call /kinetics/IP3R/bypass0_for_fig4E/notes LOAD \ "This bypass is used for pathway deletion in Fig.4E." \ "" call /kinetics/IP3R/bypass1_for_fig4E/notes LOAD \ "This bypass is used for pathway deletion in Fig.4E." \ "" call /kinetics/IP3R/bypass2_for_fig4E/notes LOAD \ "This bypass is used for pathway deletion in Fig.4E." \ "" call /kinetics/IP3R/bypass3_for_fig4E/notes LOAD \ "This bypass is used for pathway deletion in Fig.4E." \ "" call /kinetics/mGluR/notes LOAD \ "Glutamate binds to mGluRs, resulting in Gq activation. " \ "Glu released at the synaptic cleft binds to mGluRs. Activated " \ "mGluRs in turn binds to Gq to promote the exchange of GDP to " \ "GTP of Gq. An activated Gq splits into an alpha subunit " \ "(Gqalpha) and a betagamma complex (Gbetagamma). As far as we " \ "know, Fay et al. (1991) Biochemistry 30:5066-5075 is an only " \ "paper of measuring G-protein-coupled-receptor kinetics " \ "entirely, and they reported very small Gq turnover." call /kinetics/mGluR/mGluR/notes LOAD \ "Metabotropic glutamate receptor type 1. " \ "Although the characteristic of this receptor was examined in " \ "two first cloning papers (Masu et al. (1991) Nature 349:" \ "760-765; Houamed et al. (1991) Science 252:1318-1321), we " \ "cannot estimate [mGluR] because the receptors were " \ "overexpressed by functional expression in Xenopus oocytes. " \ "In Bhalla and Iyengar (1999) Scinece 283:381-387, they " \ "estimated 0.3 uM mGluR in a cell, and we took this value. " \ "Since the volume of the cytosol in the spine is 0.1 um3 in " \ "our model, the number of mGluRs was estimated to be 18. " \ "The number is similar to those of AMPARs and VGCCs in a " \ "hippocampal dendritic spine (Matsuzaki et al. (2001) Nat " \ "Neurosci 4:1086-1092; Sabatini and Svoboda (2000) Nature " \ "408:589-593). We modeled that mGluRs localize at the PSD, " \ "which has 1/50-fold volume of the cytosol. We obtained " \ "8.3333 uM mGluR in the PSD." call /kinetics/mGluR/Glu/notes LOAD \ "Glutamate released at the synaptic cleft should be removed " \ "within milliseconds because individual EPSC responses can be " \ "seen with high-frequency stimuli (100 Hz), for instance, in " \ "Takechi et al. (1998) Nature 396:757-760. Thus, we estimated " \ "that the decaying time constant of Glu is 5 msec. The initial " \ "number of Glu that access mGluRs localized at the edge of PSD " \ "was set to 300, because concentration in neurotransmitter at " \ "the edge of spine is less than that at the center of spine " \ "(Franks et al. (2003) J Neurosci 23:3186-3195). This amount " \ "of Glu is sufficient to activate most of the mGluRs." call /kinetics/mGluR/Gbc/notes LOAD \ "G-protein betagamma complex. " \ "In this simulation, there are no proteins activated by " \ "Gbetagamma." call /kinetics/mGluR/mGluR-Glu/notes LOAD \ "mGluRs activated by Glu binding." call /kinetics/mGluR/Ga-GDP/notes LOAD \ "Inactivated Gqalpha subunit. " \ "Galpha-GDP rapidly binds Gbetagamma to form a trimer." call /kinetics/mGluR/Gq-GDP/notes LOAD \ "Trimeric G-protein Gq family. " \ "In Bhalla and Iyengar (1999) Science 283:381-387, they " \ "estimated 1.0 uM Gq in a cell. Since the cytosolic volume in " \ "the spine is 0.1 um3, the number of Gq was estimated to be " \ "60. We obtained 50 uM Gq in the PSD because the cytosol has " \ "50-fold volume of the PSD." call /kinetics/mGluR/Ga-GTP/notes LOAD \ "Activated Gqalpha subunit. " \ "Gq-GTP binds PLCbeta to enhance IP3 productivity of PLCbeta." call /kinetics/mGluR/100Hz5Glu/notes LOAD \ "Input data table of Glu, 5 bursts at 100 Hz. " \ "To block the Glu release, " \ "click Buffing OFF to Buffing ON in /kinetikc/mGluR/Glu." call /kinetics/mGluR/mGluR-Gq/notes LOAD \ "mGluRs binding to Gq without Glu. " \ "It is not clear whether mGluRs and Gq form complex before " \ "ligand stimulation (small Kd), or ligand stimulation on " \ "mGluRs leads to the binding of mGluRs and Gq (large Kd). " \ "In this model, we assumed half of the mGluRs bind Gq before " \ "glutamate release." call /kinetics/mGluR/Glu-mGluR-Gq/notes LOAD \ "Intermediated state for Gq activation of Glu-mGluR-Gq complex." call /kinetics/mGluR/mGluR_bind_Gq/notes LOAD \ "The value of Kd influences whether mGluRs can bind Gq in the " \ "resting state. Higher Kd tends to allow mGluRs to bind Gq " \ "before glutamate release, whereas lower Kd does not. We " \ "assumed that half of the mGluRs are bound to Gq at the basal " \ "state." call /kinetics/mGluR/Glu_bind_mGluR-Gq/notes LOAD \ "The dependency of slow EPSCs on glutamate concentrations was " \ "measured in the first two cloning papers (Masu et al. (1991) " \ "Nature 349:760-765; Houamed et al. (1991) Science 252:1318-" \ "1321). We took the Kd value from Masu et al. (1991) Nature " \ "349:760-765." call /kinetics/mGluR/Glu_bind_mGluR/notes LOAD \ "The dependency of slow EPSCs on glutamate concentrations was " \ "measured in the first two cloning papers (Masu et al. (1991) " \ "Nature 349:760-765; Houamed et al. (1991) Science 252:1318-" \ "1321). We took the Kd value from Masu et al. (1991) Nature " \ "349:760-765." call /kinetics/mGluR/mGluR-Glu_bind_Gq/notes LOAD \ "The detailed balance determines the Kd value from the loop, " \ "mGluR -> Glu-mGluR -> Glu-mGluR-Gq -> mGluR-Gq -> mGluR." call /kinetics/mGluR/Activate_Gq/notes LOAD \ "As far as we know, there is only one paper that measured kcat " \ "for Gq activation by G-protein coupled receptors (Fay et al. " \ "(1991) Biochemistry 30:5066-5075). Unfortunately, they used " \ "muscarinic cholinergic receptors (mAchRs), not mGluRs, as " \ "G-protein coupled receptors. Reported kcat value was 0.01 " \ "/sec, and taken in two simulation papers (Fiala et al. (1996) " \ "J Neurosci 16:3760-3774; Bhalla and Iyengar (1999) Science " \ "283:381-387). This value was too small to yield micromolar " \ "IP3 concentrations in our simulation. We neglect the reported " \ "parameter value and arbitrarily assumed kcat of 116 /sec." call /kinetics/mGluR/Basal_ActGq/notes LOAD \ "Basal activity of exchange of GDP to GTP in Gq. " \ "The reaction is so slow that it can be neglected." call /kinetics/mGluR/Inact_Gq/notes LOAD \ "From Berstein et al. (1992) JBC 267:8081-8088, kcat for " \ "GTPase activity of Gq itself is only 0.8 /min. Gq " \ "inactivation is facilitated by PLC in this simulation." call /kinetics/mGluR/Trimerize_Gq/notes LOAD \ "The parameter value determines the speed of binding " \ "Gqalpha-GDP and Gbetagamma. This reaction is thought to be " \ "fast. We used the same value as in Bhalla and Iyengar (1999) " \ "Science 283:381-387. Although 6 /sec of kf might seem to be " \ "small, trimerization completes within 1 sec after glutamate " \ "stimulation." call /kinetics/Influx/CF/notes LOAD \ "CF-mediated Ca2+ influx." \ "The default delay for PF input is 0.1 sec. If you would like " \ "to change the timing, enter a value in Loop Start." call /kinetics/Influx/100Hz5PFCa/notes LOAD \ "The AMPAR pathway of PF input." call /kinetics/Influx/100Hz5PFCa-in/notes LOAD \ "If you want to block AMPA-R pathway, change Kf to 0." \ "Kf modulates the anount of Ca2+ influx by PF input." \ "The default value is 2500." call /kinetics/Influx/CF-in/notes LOAD \ "CF-mediated Ca2+ influx." \ "If you change the amount of Ca2+ influx, change Kf." \ "The default value is Kf = 4166.7" call /kinetics/IP3deg/notes LOAD \ "IP3 degradation is extensively reviewed in a simulation study " \ "(Dunplot and Erneux (1997) Cell Calcium 22:321-331). For a " \ "review for the metabolism of inositol phosphates, see Irvine " \ "and Schell (2001) Nat Rev Mol Cell Biol 2:327-338." call /kinetics/IP3deg/IP3_spine/notes LOAD \ "We set the basal [IP3] to 0.1 uM in this simulation. [IP3] " \ "measurement in living cells is difficult. The only report is " \ "Luzzi et al. (1998) J Biol Chem 273:28657-28662. They " \ "estimated 0.04 uM IP3 in Xenopus Oocytes by using capillary " \ "electrophoresis." call /kinetics/IP3deg/IP3_5-phosphatase/notes LOAD \ "IP3 5-phosphatase, which dephosphorylates IP3 to IP2. " \ "From Verjans et al. (1992) Eur J Biochem 204:1083-1087, 0.806 " \ "mg of IP5P was obtained from 2 kg of brain tissue. The yield " \ "was 15% and the molecular weight was 43000. " \ "Thus, 0.806 mg x (100%/15%) / (43000 g/mol) / 2 liter brain = " \ "0.06 uM, while assuming the specific gravity of the tissue 1 " \ "kg/liter. A study using antibodies showed that the enzyme was " \ "highly expressed in the Purkinje neurons (De Smedt et al. " \ "(1996) JBC 271:10419-10424). Thus, we increased it to 1 uM." call /kinetics/IP3deg/IP3_3-kinase/notes LOAD \ "IP3 3-kinase, which phosphorylates IP3 to IP4. " \ "In Takazawa et al. (1989) Biochem J 261:483-488, 0.020 mg of " \ "protein was purified from 700 g of bovine brain tissue. The " \ "yield was 4.4% and the molecular weight was 35000. Thus, " \ "0.020 mg x (100%/4.4%) / (35000 g/mol) / 0.7 liter = 0.019 uM " \ "while assuming the specific gravity of the tissue 1 kg/liter. " \ "This enzyme is highly localized in Purkinje dendritic spines " \ "(Yamada et al. (1993) Brain Res 606:335-340; Go et al. (1993) " \ "Neurosci Lett 158:135-138). Therefore, we increased [IP3K] to " \ "0.9 uM." call /kinetics/IP3deg/IP3K-2Ca/notes LOAD \ "Ca2+-bound state of IP3K." call /kinetics/IP3deg/IP3K-2Ca-IP3/notes LOAD \ "Ca2+- and IP3-bound state of IP3K." call /kinetics/IP3deg/IP5P-IP3/notes LOAD \ "Intermediate binding state of IP3 5-phosphatase and IP3." call /kinetics/IP3deg/IP3K-2Ca_bind_IP3/notes LOAD \ "We took the Km value from a Ca2+ simulation paper (Dunplot " \ "and Erneux (1997) Cell Calcium 22:321-331). Michaelis " \ "constant Km is 1 uM. " \ "Km = (kb + kcat) / kf = (80 + 20) / 100 = 1 uM." call /kinetics/IP3deg/IP3K_deg_IP3/notes LOAD \ "Several studies reported very different Vmax values (Irvine " \ "et al. (1986) Nature 320:631-634; Takazawa et al. (1989) " \ "Biochem J 261:483-488; Choi et al. (1990) Science 248:64-66). " \ "Thus, we did not take any reported value from these studies." call /kinetics/IP3deg/IP5P_bind_IP3/notes LOAD \ "We took the Km value from a Ca2+ simulation paper (Dunplot " \ "and Erneux (1997) Cell Calcium 22:321-331). Michaelis " \ "constant Km = 10 uM. " \ "Km = (kb + kcat) / kf = (72 + 18) / 9 = 10 uM." call /kinetics/IP3deg/IP5P_deg_IP3/notes LOAD \ "A purification study reported that Vmax = 20-35 umol/min/mg " \ "protein (Verjans et al. (1992) Eur J Biochem 204:1083-1087). " \ "IP3 5-phosphatase is a 43kDa enzyme, and we obtained " \ "kcat = 20-35 x 43000/60000 = 18 #/sec/# protein. " \ "This unit conversion method was described in De Schutter " \ "(2000) Computational Neuroscience, CRC Press, Boca Raton, " \ "pp.31." call /kinetics/IP3deg/IP3K_bind_Ca/notes LOAD \ "We took the Kd value from a Ca2+ simulation paper (Dunplot " \ "and Erneux (1997) Cell Calcium 22:321-331). " \ "Km for Ca2+ = 0.3 uM and Hill coefficient = 2." call /kinetics/PLC/notes LOAD \ "Activated PLCbeta by Gq produces IP3. " \ "Gqalpha binds to PLCbeta to enhance the PLCbeta efficiency of " \ "IP3 production. PLCbeta has GTPase activating protein (GAP) " \ "activity, which promotes ATPase efficiency of Gq by thousands " \ "times." call /kinetics/PLC/PLC-PIP2/notes LOAD \ "PLCbeta subtype 4. " \ "We modeled PLCbeta to bind PIP2 before PLC activation by " \ "Ca2+, because PIP2 concentration is high enough to bind " \ "almost all PLC in saturation. Bhalla and Iyengar (1999) " \ "Science 283:381-387 estimated 0.8 uM PLCbeta in a cell. Since " \ "the cytosolic volume in the spine is 0.1 um3, the number of " \ "Gq was estimated to be 50. We obtained 42 uM PLCbeta in the " \ "PSD because the cytosol has 50-fold volume of the PSD." call /kinetics/PLC/PLC-PIP2_bind_Gq/notes LOAD \ "The detailed balance determines the Kd value from the loop, " \ "PLC-PIP2 -> PLC-Ca-PIP2 -> PLC-Ca-Ga-PIP2 -> PLC-Gq-PIP2 -> " \ "PLC-PIP2." call /kinetics/PLC/PLC-PIP2-Gq/notes LOAD \ "This state has no enzyme activity. PLCbeta4 requires Ca2+ for " \ "activation." call /kinetics/PLC/PLC-PIP2_bind_Ca/notes LOAD \ "Ca2+-dependency of PLCbeta4 activity has not been " \ "quantitatively measured. We took the Kd value from the " \ "parameters in PLCbeta1 (Smrcka et al. (1991) Science 251:804-" \ "807), as well as Bhalla and Iyengar (1999) Science 283:381-" \ "387." call /kinetics/PLC/PLC-PIP2-Ca/notes LOAD \ "Without Gq, PLCbeta activity is very low." call /kinetics/PLC/PLC-PIP2-Gq_bind_Ca/notes LOAD \ "Ca2+-dependency of PLCbeta4 activity has not been " \ "quantitatively measured. We took the Kd value from the " \ "parameters in PLCbeta1 (Smrcka et al. (1991) Science 251:804-" \ "807), as Bhalla and Iyengar (Science 283:381-387 (1999)) did. " \ "Note that the basal [Ca2+]i is enough to activate PLC-PIP2-Gq." call /kinetics/PLC/inact_Gq_by_PLC-PIP2/notes LOAD \ "PLCbeta4 has GAP (G-protein activation protein) activity, " \ "which enhances the GTPase efficiency of Gq to thousands " \ "times. In the review of Montel (2000) Nat Cell Biol 2:E82-" \ "E83, the half-time of Gq inactivation is estimated to be 25-" \ "75 msec in the existence of PLC. We used the same activity " \ "among different PLCbeta4 states." call /kinetics/PLC/inact_Gq_by_PLC-PIP2-Ca/notes LOAD \ "PLCbeta4 has GAP (G-protein activation protein) activity, " \ "which enhances the GTPase efficiency of Gq to thousands " \ "times. In the review of Montel (2000) Nat Cell Biol 2:E82-" \ "E83, the half-time of Gq inactivation is estimated to be 25-" \ "75 msec in the existence of PLC. We used the same activity " \ "among different PLCbeta4 states." call /kinetics/PLC/PLC-PIP2-Ca-Gq/notes LOAD \ "Fully activated form of PLCbeta4. " \ "PLCbeta hydrolyzes PIP2 into DAG and IP3. PLCbeta4 activation " \ "is dependent on Gq, whereas some other PLCbeta subtypes are " \ "not." call /kinetics/PLC/PLC-PIP2-Ca_bind_Gq/notes LOAD \ "From Fig. 4 in Lee et al. (1994) JBC 269:25335-25338, " \ "affinity for Galphaq is 5 nM. Because of this high affinity, " \ "most of the activated Galpha bind PLCbeta in our simulation." call /kinetics/PLC/PLC-Ca_bind_PIP2/notes LOAD \ "A biochemical paper reported Km of 100-200 uM for PIP2 in " \ "several types of PLCbeta (James et al. (1995) JBC 270:11872-" \ "11881). We took the affinity of PLCbeta1 (Km = 170 uM)." call /kinetics/PLC/PIP2/notes LOAD \ "Phosphatidylinositol-4,5-bisphosphate. " \ "Molecular biology of the cell 4th edition says that 5000000 " \ "lipid molecules exist in a 1 um2 area of the plasma membrane. " \ "Since PIP2 is a minor lipid (less than 1%), the number of " \ "PIP2 in the PSD was estimated to be 5000." call /kinetics/PLC/PLC-Ca-Gq_bind_PIP2/notes LOAD \ "A biochemical paper reported Km of 100-200 uM for PIP2 in " \ "several types of PLCbeta (James et al. (1995) JBC 270:11872-" \ "11881). We took the affinity of PLCbeta1 (Km = 170 uM)." call /kinetics/PLC/PLC-Ca_bind_Gq/notes LOAD \ "From Fig. 4 in Lee et al. (1994) JBC 269:25335-25338, " \ "affinity for Galphaq is 5 nM. Because of this high affinity, " \ "most of the activated Galpha bind PLCbeta in our simulation." call /kinetics/PLC/PLC-Ca/notes LOAD \ "The intermediate states of PLCbeta that do not bind PIP2. " \ "We assumed that PLCbeta in the basal states bind PIP2." call /kinetics/PLC/PLC-Ca-Gq/notes LOAD \ "The intermediate states of PLCbeta that do not bind PIP2. " \ "We assumed that PLCbeta in the basal states bind PIP2." call /kinetics/PLC/IP3_PSD/notes LOAD \ "IP3 is produced by PLCbeta in the PSD and diffuses to the " \ "cytosol." call /kinetics/PLC/DAG/notes LOAD \ "Diacylglycerol activates no enzyme in the model because we do " \ "not implement DAG-dependent enzymes such as protein kinase C." call /kinetics/PLC/IP3_prd_without_Gq/notes LOAD \ "PLCbeta4 has basal activity of IP3 production without Gq. " \ "The measurement of this activity is difficult because " \ "PLCbeta4 is inhibited by ribonucleotides (Lee et al. (1994) " \ "JBC 269:25335-25338). Therefore, we assumed this parameter to " \ "hold basal [IP3] at 0.1 uM." call /kinetics/PLC/IP3_prd_with_Gq/notes LOAD \ "The measurement of this enzyme activity is difficult because " \ "PLCbeta4 is inhibited by ribonucleotides (Lee et al. (1994) " \ "JBC 269:25335-25338). We used the activity of PLCbeta1 in " \ "Mishra and Bhalla (2002) Biophys J 83:1298-1316." call /kinetics/PLC/inact_Gq_by_PLC-Ca/notes LOAD \ "PLCbeta4 has GAP (G-protein activation protein) activity, " \ "which enhances the GTPase efficiency of Gq to thousands " \ "times. In the review of Montel (2000) Nat Cell Biol 2:E82-" \ "E83, the half-time of Gq inactivation is estimated to be 25-" \ "75 msec in the existence of PLC. We used the same activity " \ "among different PLCbeta4 states." call /kinetics/PLC/basalCa_for_fig4D/notes LOAD \ "Basal [Ca2+]i = 0.06 uM." \ "" call /kinetics/PLC/bypass0_for_fig4D/notes LOAD \ "This bypass is used for pathway deletion in Fig.4D." \ "" call /kinetics/PLC/bypass1_for_fig4D/notes LOAD \ "This bypass is used for pathway deletion in Fig.4D." \ "" call /kinetics/CaReg/notes LOAD \ "We modeled Ca2+ release through the IP3R Ca2+ channels, Ca2+ " \ "leaks through the plasma membrane and ER, and Ca2+ clearance " \ "by Ca2+ pumps (SERCA and PMCA) and exchangers. We assumed " \ "that molecules do not diffuse through the spine neck." call /kinetics/CaReg/Ca2+/proto/CaSpine/notes LOAD \ "Free cytosolic Ca2+ concentration, [Ca2+]i. " \ "The basal [Ca2+]i is set to 0.06 uM." call /kinetics/CaReg/IP3R/proto/IP3R/notes LOAD \ "IP3Rs are only Ca2+ channels in ER at dendritic spines of " \ "Purkinje cells. No ryanodine receptors are in the spines." call /kinetics/CaReg/IP3R/proto/IP3R/IP3R_Ca_channel/notes LOAD \ "In Bezprozvanny and Ehrich (1994) J Gen Physiol 104:821-856, " \ "they estimated that 5400 Ca2+ ions go through an open IP3R " \ "per second at 2500 uM [Ca2+]ER. The unit of permability is " \ "not described in GENESIS/kinetikit, but we found that the " \ "parameter value of 450 matches the estimation." call /kinetics/CaReg/Ca_diff/notes LOAD \ "The time constant tau = 1 ms." call /kinetics/CaReg/Ca2+PSD/proto/Ca2+PSD/notes LOAD \ "Ca2+ concentration in the postsynaptic density. This " \ "concentration is used only for Ca2+-dependent PLCbeta " \ "activation. It has a slight effect on IP3 productivity of " \ "PLCbeta in the PSD." call /kinetics/CaReg/SERCA/notes LOAD \ "Sacro- and endoplasmic reticulum Ca2+-ATPase. " \ "SERCA is a dominant protein in the ER, constituting 80% of " \ "the ER membrane protein (Stryer Biochemistry 5th edition). " \ "SERCA type 2 is dominant in the Purkinje cells (Takei et al. " \ "(1992) J Neurosci 12:489-505). We assumed the number of SERCA " \ "so that [Ca2+]ER is 150 uM at the basal state." call /kinetics/CaReg/PMCA/notes LOAD \ "Plasma membrane Ca2+-ATPase. " \ "Type 2 of PMCA is abundant in Purkinje cells (de Talamoni et " \ "al. (1993) PNAS 90:11949-11953). PMCA has higher affinity and " \ "lower capacity than Na+/Ca2+ exchangers. At the basal " \ "[Ca2+]i, PMCA pumps out much more Ca2+ ions than Na+/Ca2+. We " \ "chose [PMCA] so that [Ca2+]i is 0.06 uM at the basal state." call /kinetics/CaReg/NCX/notes LOAD \ "Na+/Ca2+ exchangers. " \ "They use Na+ electrochemical gradient across the plasma " \ "membrane as their energy source. Note that we do not model " \ "membrane potential. NCXs play a major role in pumping out " \ "intracellular Ca2+ at micromolar levels of [Ca2+]i." call /kinetics/CaReg/Castore_dend/notes LOAD \ "The Ca stores in spine are continuous dendritic shafts and " \ "the soma. We assume that the Ca2+ diffusion out of the " \ "dendritic spine is neglectable in a few seconds simulation." call /kinetics/CaReg/calreticulin/notes LOAD \ "A well-known Ca2+ buffer in the ER. " \ "We took the Ca2+ biding ratio in the ER to be 5. Bound Ca2+ " \ "is 5 times free Ca2+ in the ER at the basal [Ca2+]ER." call /kinetics/CaReg/calreticulin-Ca/notes LOAD \ "Ca2+-bound state of calreticulin. " \ "[calreticulin-Ca] = 2,500 uM. [Ca2+]ER = 500 uM. " \ "Thus, the biding ratio is 2,500/500 = 5." call /kinetics/CaReg/CaStore/notes LOAD \ "Free Ca2+ concentration in the ER, [Ca2+]ER, was previously " \ "assumed to be more than 1 mM in 1990s (for example, Fiala et " \ "al. (1996) J Neurosci 16:3760-3774; Bezprozvanny and Ehrich " \ "(1994) J Gen Physiol 104:821-856). Recent studies using low-" \ "affinity Ca2+ indicators implied [Ca2+]ER at submicromolar " \ "levels (e.g. Park et al. (2000) EMBO J 19:5729-5739). Thus, " \ "we used 150 uM [Ca2+]ER in the simulation." call /kinetics/CaReg/SERCA-2Ca/notes LOAD \ "Ca2+-bound state of SERCA. " call /kinetics/CaReg/PMCA-Ca/notes LOAD \ "Ca2+-bound state of PMCA." call /kinetics/CaReg/NCX-2Ca/notes LOAD \ "Ca2+-bound state of Na+/Ca2+ exchangers. " call /kinetics/CaReg/SERCA_uptake/notes LOAD \ "In Stryer Biochemistry 5th edition, one SERCA pumps out less " \ "than 100 Ca2+ ions per second. Thus, we took kcat value to be " \ "50 /s at first, but the low kcat value caused a problem. The " \ "speed of Ca2+ clearance does not increase inproportion to the " \ "number of Ca2+ pumps because free Ca2+ concentration becomes " \ "low and the Ca2+ binding to the pump decreases in the large " \ "presence of Ca2+ pumps with low kcat. We failed to reproduce " \ "Ca2+ time course showed in Wang et al. (2000) Nat Neurosci 3:" \ "1266-1273 even if we increased the number of pumps. Following " \ "the fact that most of the other Ca2+ simulation neglect the " \ "binding effect of Ca2+ pumps, we decided to reduce the " \ "buffing effect by adjusting kcat and [SERCA], while keeping " \ "Vmax (= kcat x [SERCA]). Thus, we increased kcat 5-fold and " \ "decreased [SERCA] 1/5-fold." call /kinetics/CaReg/NCX_bind_2Ca/notes LOAD \ "Since this model does not include voltage, the efficacy of " \ "Na+/Ca2+ uptake should be dependent only on Ca2+ " \ "concentration, not on the membrane potential. In Fujioka et " \ "al. (2000) J Physiol 529:611-623, they measured Ca2+-" \ "dependent current of Na+/Ca2+. Km for Ca2+ = 7.3 uM and the " \ "Hill coefficient = 2. " \ "Km^2 = (kb + kcat) / kf = (4000 + 1000) / 93.287 = (7.3 uM)^2." call /kinetics/CaReg/PMCA_bind_Ca/notes LOAD \ "We took the kinetic parameters of PMCA subtype 2 from " \ "Stauffer et al. (1995) JBC 270:12184-12190. Km = 0.1 uM and " \ "Hill coefficient = 1. " \ "Km = (kb + kcat) / kf = (500 + 2000) / 25000 = 0.1 uM." call /kinetics/CaReg/Ca_bind_calreticulin/notes LOAD \ "Calreticulin is a high-concentration and uncooperative " \ "buffer. We took Kd to be 2 mM, based on Krause and Michalak " \ "(1997) Cell 88:439-443." call /kinetics/CaReg/CaStore_Dif/notes LOAD \ "The model has no Ca2+ diffusion out of the dendritic spine." call /kinetics/CaReg/SERCA_bind_2Ca/notes LOAD \ "We took the kinetics parameter of SERCA subtype 2b from " \ "Lytton et al. (1992) JBC 267:14483-14489. Km = 0.27 uM and " \ "the Hill coefficient = 2. " \ "Km^2 = (kb + kcat) / kf = (1000 + 250) / 17147 = (0.27 uM)^2." call /kinetics/CaReg/Ca_Leak_from_ER/Ca_Leak_chan_from_ER/notes LOAD \ "This leak parameter was dependent on other parameters of Ca2+ " \ "regulation." call /kinetics/CaReg/PMCA_uptake/notes LOAD \ "The capacity of PMCA was increased to 10 times (50 to 500) " \ "for the same reason as the increase in kcat for SERCA." call /kinetics/CaReg/NCX_uptake/notes LOAD \ "Stryer Biochemistry 5th edition says that a Na+/Ca2+ can " \ "extrude 2000 Ca2+ ions per second. Since the Hill coefficient " \ "is 2, a Na+/Ca2+ transports two Ca2+ ions at one reaction " \ "cycle. Thus, kcat = 2000/2 = 1000 /s." call /kinetics/CaReg/Ca_ext/notes LOAD \ "Extracellular Ca2+ concentration." call /kinetics/CaReg/Ca_Leak_from_ext/Ca_Leak_chan_from_ext/notes LOAD \ "This leak parameter was dependent on other parameters of Ca2+ " \ "regulation." call /kinetics/CaBuf/notes LOAD \ "In cells, 99% of the Ca2+ ions are buffered with endogenous " \ "Ca2+-binding proteins. In particular, cerebellar Purkinje " \ "cells contain Ca2+ buffers at high concentrations, and the " \ "binding ratio is more than 1000 (Fierro and Llano (1996) J " \ "Physiol 496:617-625). In addition, Ca2+ indicators play a " \ "role of exogenous buffers. The binding ratio dependent on " \ "[Ca2+]i was extensively investigated in Maeda et al. (1999) " \ "Neuron 24:989-1002." call /kinetics/CaBuf/Calbindin-D28k/notes LOAD \ "Calbindin-D28k is highly expressed in Purkinje cells. Ca2+ " \ "decay in mutant mice with no calbindin-D28k gene was faster " \ "than in wild-type mice (Airaksinen et al. (1997) PNAS " \ "94:1488-1493). Although Maeda et al. (Neuron 24:989-1002 " \ "(1999)) studied the effect of Ca2+ buffers in cerebellar " \ "Purkinje cells and estimated 360 uM [CB], they neglected " \ "effects of other high-affinity buffers and Ca2+ pumps " \ "dependent on [Ca2+]i. [CB] was estimated to be 100 uM in our " \ "simulation." call /kinetics/CaBuf/parvalbumin/notes LOAD \ "Parvalbumin is highly expressed in GABAergic neurons, " \ "including Purkinje cells (de Talamoni et al. (1993) PNAS " \ "90:11949-11953). Considering the high binding ratio at the " \ "basal [Ca2+]i (Fierro and Llano (1996) J Physiol " \ "496:617-625), the concentration in parvalbumin should be " \ "tens of micromolars." call /kinetics/CaBuf/PV-Ca/notes LOAD \ "Ca2+-bound state of parvalbumin." call /kinetics/CaBuf/LowAffBuf/notes LOAD \ "Purkinje cells contain low-affinity buffers at high " \ "concentrations (Maeda et al. (1999) Neuron 24:989-1002). We " \ "fitted the binding ratio in our model to the binding ratio " \ "in their Fig. 6 by using two buffers. Low-affinity buffer 1 " \ "(LAB) is non-cooperative, and Hill coefficient is 1." call /kinetics/CaBuf/LowAffBuf2/notes LOAD \ "Purkinje cells contain low-affinity buffers at high " \ "concentration (Maeda et al. (1999) Neuron 24:989-1002). We " \ "fitted the binding ratio in our model to the binding ratio " \ "in their Fig. 6 by using two buffers. Low-affinity buffer 2 " \ "(LAB2) is cooperative, and the Hill coefficient is 2." call /kinetics/CaBuf/MgGreen/notes LOAD \ "Magnesium Green 1. " \ "This low-affinity Ca2+ indicator was used at 250-500 uM in " \ "Wang et al. (2000) Nat Neurosci 3:1266-1273. To compare our " \ "simulation results with the Ca2+ imaging directly, we " \ "included 250 uM MgGreen in our model." call /kinetics/CaBuf/Ca_bind_MgGreen/notes LOAD \ "Apparent Kd of Magnesium Green 1 for Ca2+ is 19 uM in the " \ "presence of endogenous Mg2+, from Wang et al. (2000) Nat " \ "Neurosci 3:1266-1273." call /kinetics/CaBuf/PV_bind_Ca/notes LOAD \ "Parvalbumin is a slow and high-affinity buffer. Most of the " \ "parvalbumin binds endogenous Mg2+ at the basal Ca2+ " \ "concentration. In Lee et al. (2000) J Physiol 525:419-431, " \ "they measured the apparent dissociation constant Kd = 0.0514 " \ "uM and the unbinding rate constant kb = 0.95 /sec in the " \ "presence of Mg2+, and we used the parameter values." call /kinetics/CaBuf/CB_bind_2Ca/notes LOAD \ "Calbindin is a cooperative and high-affinity buffer. We took " \ "the Kd value and the Hill coefficient to be 0.36 uM and 2, " \ "from Maeda et al. (1999) Neuron 24:989-1002. These values " \ "were consistent with (2:2) ratio in Table 1 in Nagerl et al. " \ "(2000) Biophys J 79:3009-3018." call /kinetics/CaBuf/CB-2Ca/notes LOAD \ "Ca2+-bound state of calbindin-D28k. " call /kinetics/CaBuf/LAB-Ca/notes LOAD \ "Ca2+-bound state of low-affinity buffer 1." call /kinetics/CaBuf/LAB_bind_Ca/notes LOAD \ "We included low-affinity buffers based on Fig. 6 in Maeda et " \ "al. (1999) Neuron 24:989-1002. The Hill coefficients of low- " \ "affinity buffer 1 (LAB) and low-affinity buffer 2 (LAB2) were " \ "taken 1 and 2, respectively." call /kinetics/CaBuf/LAB2_bind_2Ca/notes LOAD \ "We included low-affinity buffers based on Fig. 6 in Maeda et " \ "al. (1999) Neuron 24:989-1002. The Hill coefficients of low- " \ "affinity buffer 1 (LAB) and low-affinity buffer 2 (LAB2) were " \ "taken 1 and 2, respectively." call /kinetics/CaBuf/LAB2-2Ca/notes LOAD \ "Ca2+-bound state of low-affinity buffer 2." call /kinetics/CaBuf/MgGreen*/notes LOAD \ "Ca2+-bound form of MgGreen. " \ "MgGreen* (Ca2+-bound form) has twice the fluorescence of " \ "MgGreen (Ca2+-nonbound form). Thus, Fmax/Fmin = 2." complete_loading