//genesis // kkit Version 11 flat dumpfile // Saved on Thu Nov 9 11:27:46 2006 include kkit {argv 1} FASTDT = 5e-06 SIMDT = 5e-06 CONTROLDT = 0.1 PLOTDT = 0.1 MAXTIME = 5900.1 TRANSIENT_TIME = 302 VARIABLE_DT_FLAG = 0 DEFAULT_VOL = 1.6667e-21 VERSION = 11.0 setfield /file/modpath value /home2/bhalla/scripts/modules kparms //genesis initdump -version 3 -ignoreorphans 1 simobjdump doqcsinfo filename accessname accesstype transcriber developer \ citation species tissue cellcompartment methodology sources \ model_implementation model_validation x y z simobjdump table input output alloced step_mode stepsize x y z simobjdump xtree path script namemode sizescale simobjdump xcoredraw xmin xmax ymin ymax simobjdump xtext editable simobjdump xgraph xmin xmax ymin ymax overlay simobjdump xplot pixflags script fg ysquish do_slope wy simobjdump group xtree_fg_req xtree_textfg_req plotfield expanded movealone \ link savename file version md5sum mod_save_flag x y z simobjdump geometry size dim shape outside xtree_fg_req xtree_textfg_req x y \ z simobjdump kpool DiffConst CoInit Co n nInit mwt nMin vol slave_enable \ geomname xtree_fg_req xtree_textfg_req x y z simobjdump kreac kf kb notes xtree_fg_req xtree_textfg_req x y z simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol k1 k2 k3 \ keepconc usecomplex notes xtree_fg_req xtree_textfg_req link x y z simobjdump stim level1 width1 delay1 level2 width2 delay2 baselevel trig_time \ trig_mode notes xtree_fg_req xtree_textfg_req is_running x y z simobjdump xtab input output alloced step_mode stepsize notes editfunc \ xtree_fg_req xtree_textfg_req baselevel last_x last_y is_running x y z simobjdump kchan perm gmax Vm is_active use_nernst notes xtree_fg_req \ xtree_textfg_req x y z simobjdump transport input output alloced step_mode stepsize dt delay clock \ kf xtree_fg_req xtree_textfg_req x y z simobjdump proto x y z simundump geometry /kinetics/geometry 0 1.6667e-21 3 sphere "" white black 0 \ 0 0 simundump group /kinetics/MAPK 0 red black x 0 0 "" red \ /home2/bhalla/scripts/modules/red_0.g 0 0 0 -83 148 0 simundump kpool /kinetics/MAPK/Raf 0 0 0.5 0.5 0.5 0.5 0 0 1 0 \ /kinetics/geometry cyan red -79 147 0 simundump kpool /kinetics/MAPK/MEK 0 0 0.5 0.5 0.5 0.5 0 0 1 0 \ /kinetics/geometry cyan red -80 141 0 simundump kpool /kinetics/MAPK/MEK-P 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ cyan red -76 141 0 simundump kpool /kinetics/MAPK/MEK-PP 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ #ffdf00 red -72 141 0 simundump kenz /kinetics/MAPK/MEK-PP/MEK_act_MAPK-P 0 0 0 0 0 1 16.2 0.6 0.15 \ 0 0 "" red #ffdf00 "" -74 136 0 simundump kenz /kinetics/MAPK/MEK-PP/MEK_act_MAPK 0 0 0 0 0 1 16.2 0.6 0.15 0 \ 0 "" red #ffdf00 "" -78 136 0 simundump kpool /kinetics/MAPK/MKP1 0 0 0.0032 0.0032 0.0032 0.0032 0 0 1 0 \ /kinetics/geometry brown red -76 129 0 simundump kenz /kinetics/MAPK/MKP1/MKP_deph_MAPK-P 0 0 0 0 0 1 29.999 4 1 0 0 \ "" red brown "" -78 130 0 simundump kenz /kinetics/MAPK/MKP1/MKP_deph_MAPK-PP 0 0 0 0 0 1 29.999 4 1 0 \ 0 "" red brown "" -73 130 0 simundump kpool /kinetics/MAPK/MAPK 0 0 1 1 1 1 0 0 1 0 /kinetics/geometry \ cyan red -80 133 0 simundump kpool /kinetics/MAPK/MAPK-P 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ cyan red -76 133 0 simundump kpool /kinetics/MAPK/Raf-P 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ #ffff00 red -71 147 0 simundump kenz /kinetics/MAPK/Raf-P/Raf_act_MEK 0 0 0 0 0 1 1.3191 0.42 0.105 \ 0 0 "" red #ffff00 "" -78 143 0 simundump kenz /kinetics/MAPK/Raf-P/Raf_act_MEK-P 0 0 0 0 0 1 1.3191 0.42 \ 0.105 0 0 "" red #ffff00 "" -74 143 0 simundump kpool /kinetics/MAPK/MAPK-PP 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ #ff4400 red -72 133 0 simundump kenz /kinetics/MAPK/MAPK-PP/MAPK_phos_PLA2 0 0 0 0 0 1 3.9062 80 20 \ 0 0 "" red #ff4400 "" -51 132 0 simundump kpool /kinetics/MAPK/PP2A 0 0 0.045 0.045 0.045 0.045 0 0 1 0 \ /kinetics/geometry maroon red -76 138 0 simundump kenz /kinetics/MAPK/PP2A/PP2A_deph_MEK-PP 0 0 0 0 0 1 1.9108 24 6 0 \ 0 "" red maroon "" -73 139 0 simundump kenz /kinetics/MAPK/PP2A/PP2A_deph_MEK-P 0 0 0 0 0 1 1.9108 24 6 0 \ 0 "" red maroon "" -78 139 0 simundump kenz /kinetics/MAPK/PP2A/PP2A_deph_AMPAR 0 0 0 0 0 1 1.9108 24 6 0 \ 0 "" red maroon "" -73 154 0 simundump kenz /kinetics/MAPK/PP2A/PP2A_deph_Raf-P 0 0 0 0 0 1 1.9108 24 6 0 \ 0 "" red maroon "" -75 145 0 simundump group /kinetics/PLA2 0 springgreen black x 0 0 "" yellow \ /home2/bhalla/scripts/modules/yellow_0.g 0 0 0 -35 143 0 simundump kpool /kinetics/PLA2/PLA2 0 0 0.4 0.4 0.4 0.4 0 0 1 0 \ /kinetics/geometry blue springgreen -47 134 0 simundump kpool /kinetics/PLA2/PLA2-Ca 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ blue springgreen -47 140 0 simundump kenz /kinetics/PLA2/PLA2-Ca/PLA2-Ca_prd_AA 0 0 0 0 0 1 13.5 216 54 \ 0 0 "" red blue "" -44 149 0 simundump kreac /kinetics/PLA2/PLA2_bind_Ca 0 0.01 0.1 "" seagreen \ springgreen -47 137 0 simundump kpool /kinetics/PLA2/PLA2-P 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ red springgreen -47 130 0 simundump kenz /kinetics/PLA2/PLA2-P/PLA2-P_prd_AA 0 0 0 0 0 1 30 480 120 0 0 \ "" red red "" -40 146 0 simundump kpool /kinetics/PLA2/APC 0 0 30 30 30 30 0 0 1 4 /kinetics/geometry \ purple springgreen -35 146 0 simundump kreac /kinetics/PLA2/AA_deg 0 0.4 0 "" white springgreen -40 143 0 simundump kreac /kinetics/PLA2/PLA2-P_deg 0 0.17 0 "" white springgreen -43 \ 132 0 simundump kpool /kinetics/PLA2/PIP2 0 0 10 10 10 10 0 0 1 4 \ /kinetics/geometry seagreen springgreen -41 137 0 simundump kpool /kinetics/PLA2/AA 0 0 0.4 0.4 0.4 0.4 0 0 1 0 \ /kinetics/geometry violet springgreen -45 146 0 simundump kpool /kinetics/PLA2/Ca 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ orange springgreen -52 135 0 simundump kreac /kinetics/PLA2/PLA2_bind_PIP2 0 0.0012 0.48 "" white \ springgreen -41 134 0 simundump kpool /kinetics/PLA2/PLA2-PIP2 0 0 0 0 0 0 0 0 1 0 \ /kinetics/geometry blue springgreen -36 134 0 simundump kenz /kinetics/PLA2/PLA2-PIP2/PLA2-PIP2_prd_AA 0 0 0 0 0 1 2.76 \ 44.16 11.04 0 0 "" red blue "" -40 148 0 simundump kpool /kinetics/PLA2/PLA2-PIP2-Ca 0 0 0 0 0 0 0 0 1 0 \ /kinetics/geometry blue springgreen -36 140 0 simundump kenz /kinetics/PLA2/PLA2-PIP2-Ca/PLA2-PIP2-Ca_prd_AA 0 0 0 0 0 1 9 \ 144 36 0 0 "" red blue "" -37 149 0 simundump kreac /kinetics/PLA2/PLA2-Ca_bind_PIP2 0 0.0012 0.48 "" white \ springgreen -41 140 0 simundump kreac /kinetics/PLA2/PLA2-PIP2_bind_Ca 0 0.01 0.1 "" white \ springgreen -36 137 0 simundump group /kinetics/PKC 0 slateblue black x 0 0 "" yellow \ /home2/bhalla/scripts/modules/yellow_0.g 0 0 0 -60 153 0 simundump kpool /kinetics/PKC/PKC 0 0 1 1 1 1 0 0 1 0 /kinetics/geometry \ seagreen slateblue -53 147 0 simundump kreac /kinetics/PKC/PKC_bind_Ca 0 0.25 1 "" seagreen slateblue -56 \ 149 0 simundump kreac /kinetics/PKC/PKC_bind_AA 0 0.2 10 "" seagreen slateblue -50 \ 150 0 simundump kpool /kinetics/PKC/PKC_active 0 0 0 0 0 0 0 0 1 0 \ /kinetics/geometry cyan slateblue -53 160 0 simundump kenz /kinetics/PKC/PKC_active/PKC_phos_AMPAR 0 0 0 0 0 1 0.071431 \ 0.2 0.05 0 0 "" red cyan "" -72 160 0 simundump kenz /kinetics/PKC/PKC_active/PKC_phos_Raf 0 0 0 0 0 1 0.014565 \ 0.134 0.0335 0 0 "" red cyan "" -75 149 0 simundump kreac /kinetics/PKC/PKC-Ca_bind_AA 0 0.2 10 "" seagreen slateblue \ -52 151 0 simundump kpool /kinetics/PKC/PKC-Ca 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ orange slateblue -56 155 0 simundump kpool /kinetics/PKC/PKC-Ca-AA 0 0 0 0 0 0 0 0 1 0 \ /kinetics/geometry magenta slateblue -53 158 0 simundump kpool /kinetics/PKC/PKC-AA 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ pink slateblue -50 157 0 simundump kreac /kinetics/PKC/PKC-AA_bind_Ca 0 0.25 1 "" seagreen slateblue \ -54 150 0 simundump kpool /kinetics/PKC/Ca 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ orange slateblue -60 149 0 simundump kpool /kinetics/PKC/PKC_deg 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ maroon slateblue -45 158 0 simundump kreac /kinetics/PKC/PKC-Ca_deg 0 0 0 "" white slateblue -48 156 0 simundump kreac /kinetics/PKC/PKC-AA_deg 0 0 0 "" white slateblue -48 157 0 simundump kreac /kinetics/PKC/PKC-Ca-AA_deg 0 0 0 "" white slateblue -49 158 \ 0 simundump kpool /kinetics/PKC/PKC-Ca_cyto 0 0 0 0 0 0 0 0 1 0 \ /kinetics/geometry red slateblue -56 151 0 simundump kreac /kinetics/PKC/PKC-Ca_memb 0 1 0.1 "" white slateblue -56 153 \ 0 simundump group /kinetics/AMPAR 0 darkgreen black x 0 0 "" AMPAR \ /home2/bhalla/scripts/modules/AMPA_0.g 0 0 0 -73 157 0 simundump kpool /kinetics/AMPAR/AMPAR-P 0 0 0 0 0 0 0 0 1 0 \ /kinetics/geometry yellow darkgreen -69 157 0 simundump kpool /kinetics/AMPAR/AMPAR 0 0 0.5 0.5 0.5 0.5 0 0 1 0 \ /kinetics/geometry green darkgreen -76 157 0 simundump kpool /kinetics/CaInput 0 0 0 0 0 0 0 0 1 0 /kinetics/geometry \ orange black -60 139 0 simundump kpool /kinetics/CaSource 0 0 1 1 1 1 0 0 1 4 /kinetics/geometry \ orange black -60 135 0 simundump kreac /kinetics/ramp 0 0 0 "" white black -60 137 0 simundump xgraph /graphs/conc1 0 0 6000 0 100 0 simundump xgraph /graphs/conc2 0 0 6000 0 0.5 0 simundump xplot /graphs/conc1/CaInput.Co 3 524288 \ "delete_plot.w ; edit_plot.D " orange 0 0 1 simundump xplot /graphs/conc1/AA.Co 3 524288 \ "delete_plot.w ; edit_plot.D " violet 0 0 1 simundump xplot /graphs/conc2/AMPAR.Co 3 524288 \ "delete_plot.w ; edit_plot.D " green 0 0 1 simundump xplot /graphs/conc2/AMPAR-P.Co 3 524288 \ "delete_plot.w ; edit_plot.D " yellow 0 0 1 simundump xgraph /moregraphs/conc3 0 0 60 0 1 0 simundump xgraph /moregraphs/conc4 0 0 6000 0 1 0 simundump xplot /moregraphs/conc3/PKC-Ca.Co 3 524288 \ "delete_plot.w ; edit_plot.D " orange 0 0 1 simundump xplot /moregraphs/conc3/PKC-AA.Co 3 524288 \ "delete_plot.w ; edit_plot.D " pink 0 0 1 simundump xplot /moregraphs/conc3/PKC-Ca-AA.Co 3 524288 \ "delete_plot.w ; edit_plot.D " magenta 0 0 1 simundump xplot /moregraphs/conc3/PKC_active.Co 3 524288 \ "delete_plot.w ; edit_plot.D " cyan 0 0 1 simundump xplot /moregraphs/conc3/PKC_deg.Co 3 524288 \ "delete_plot.w ; edit_plot.D " maroon 0 0 1 simundump xplot /moregraphs/conc3/PKC-Ca_cyto.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xplot /moregraphs/conc4/Raf-P.Co 3 524288 \ "delete_plot.w ; edit_plot.D " #ffff00 0 0 1 simundump xplot /moregraphs/conc4/MEK-PP.Co 3 524288 \ "delete_plot.w ; edit_plot.D " #ffdf00 0 0 1 simundump xplot /moregraphs/conc4/MAPK-PP.Co 3 524288 \ "delete_plot.w ; edit_plot.D " #ff4400 0 0 1 simundump xplot /moregraphs/conc4/PLA2-P.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xcoredraw /edit/draw 0 -58.921 -42.603 150.67 161.66 simundump xtree /edit/draw/tree 0 \ /kinetics/#[],/kinetics/#[]/#[],/kinetics/#[]/#[]/#[][TYPE!=proto],/kinetics/#[]/#[]/#[][TYPE!=linkinfo]/##[] \ "edit_elm.D ; drag_from_edit.w " auto 0.6 simundump xtext /file/notes 0 1 xtextload /file/notes \ "f102flash.g is modified based on doi_LTD6.g" \ "Add PKC translocation to memb." \ "No PKC deg." \ "Fix PLA2 affitnity for Ca." \ "Slow translocation of PKC-Ca" addmsg /kinetics/MAPK/PP2A/PP2A_deph_Raf-P /kinetics/MAPK/Raf MM_PRD pA addmsg /kinetics/PKC/PKC_active/PKC_phos_Raf /kinetics/MAPK/Raf REAC sA B addmsg /kinetics/MAPK/Raf-P/Raf_act_MEK /kinetics/MAPK/MEK REAC sA B addmsg /kinetics/MAPK/PP2A/PP2A_deph_MEK-P /kinetics/MAPK/MEK MM_PRD pA addmsg /kinetics/MAPK/Raf-P/Raf_act_MEK /kinetics/MAPK/MEK-P MM_PRD pA addmsg /kinetics/MAPK/Raf-P/Raf_act_MEK-P /kinetics/MAPK/MEK-P REAC sA B addmsg /kinetics/MAPK/PP2A/PP2A_deph_MEK-PP /kinetics/MAPK/MEK-P MM_PRD pA addmsg /kinetics/MAPK/PP2A/PP2A_deph_MEK-P /kinetics/MAPK/MEK-P REAC sA B addmsg /kinetics/MAPK/Raf-P/Raf_act_MEK-P /kinetics/MAPK/MEK-PP MM_PRD pA addmsg /kinetics/MAPK/PP2A/PP2A_deph_MEK-PP /kinetics/MAPK/MEK-PP REAC sA B addmsg /kinetics/MAPK/MEK-PP/MEK_act_MAPK /kinetics/MAPK/MEK-PP REAC eA B addmsg /kinetics/MAPK/MEK-PP/MEK_act_MAPK-P /kinetics/MAPK/MEK-PP REAC eA B addmsg /kinetics/MAPK/MEK-PP /kinetics/MAPK/MEK-PP/MEK_act_MAPK-P ENZYME n addmsg /kinetics/MAPK/MAPK-P /kinetics/MAPK/MEK-PP/MEK_act_MAPK-P SUBSTRATE n addmsg /kinetics/MAPK/MEK-PP /kinetics/MAPK/MEK-PP/MEK_act_MAPK ENZYME n addmsg /kinetics/MAPK/MAPK /kinetics/MAPK/MEK-PP/MEK_act_MAPK SUBSTRATE n addmsg /kinetics/MAPK/MKP1/MKP_deph_MAPK-P /kinetics/MAPK/MKP1 REAC eA B addmsg /kinetics/MAPK/MKP1/MKP_deph_MAPK-PP /kinetics/MAPK/MKP1 REAC eA B addmsg /kinetics/MAPK/MKP1 /kinetics/MAPK/MKP1/MKP_deph_MAPK-P ENZYME n addmsg /kinetics/MAPK/MAPK-P /kinetics/MAPK/MKP1/MKP_deph_MAPK-P SUBSTRATE n addmsg /kinetics/MAPK/MKP1 /kinetics/MAPK/MKP1/MKP_deph_MAPK-PP ENZYME n addmsg /kinetics/MAPK/MAPK-PP /kinetics/MAPK/MKP1/MKP_deph_MAPK-PP SUBSTRATE n addmsg /kinetics/MAPK/MEK-PP/MEK_act_MAPK /kinetics/MAPK/MAPK REAC sA B addmsg /kinetics/MAPK/MKP1/MKP_deph_MAPK-P /kinetics/MAPK/MAPK MM_PRD pA addmsg /kinetics/MAPK/MEK-PP/MEK_act_MAPK /kinetics/MAPK/MAPK-P MM_PRD pA addmsg /kinetics/MAPK/MEK-PP/MEK_act_MAPK-P /kinetics/MAPK/MAPK-P REAC sA B addmsg /kinetics/MAPK/MKP1/MKP_deph_MAPK-P /kinetics/MAPK/MAPK-P REAC sA B addmsg /kinetics/MAPK/MKP1/MKP_deph_MAPK-PP /kinetics/MAPK/MAPK-P MM_PRD pA addmsg /kinetics/MAPK/Raf-P/Raf_act_MEK /kinetics/MAPK/Raf-P REAC eA B addmsg /kinetics/MAPK/Raf-P/Raf_act_MEK-P /kinetics/MAPK/Raf-P REAC eA B addmsg /kinetics/MAPK/PP2A/PP2A_deph_Raf-P /kinetics/MAPK/Raf-P REAC sA B addmsg /kinetics/PKC/PKC_active/PKC_phos_Raf /kinetics/MAPK/Raf-P MM_PRD pA addmsg /kinetics/MAPK/Raf-P /kinetics/MAPK/Raf-P/Raf_act_MEK ENZYME n addmsg /kinetics/MAPK/MEK /kinetics/MAPK/Raf-P/Raf_act_MEK SUBSTRATE n addmsg /kinetics/MAPK/Raf-P /kinetics/MAPK/Raf-P/Raf_act_MEK-P ENZYME n addmsg /kinetics/MAPK/MEK-P /kinetics/MAPK/Raf-P/Raf_act_MEK-P SUBSTRATE n addmsg /kinetics/MAPK/MEK-PP/MEK_act_MAPK-P /kinetics/MAPK/MAPK-PP MM_PRD pA addmsg /kinetics/MAPK/MKP1/MKP_deph_MAPK-PP /kinetics/MAPK/MAPK-PP REAC sA B addmsg /kinetics/MAPK/MAPK-PP/MAPK_phos_PLA2 /kinetics/MAPK/MAPK-PP REAC eA B addmsg /kinetics/MAPK/MAPK-PP /kinetics/MAPK/MAPK-PP/MAPK_phos_PLA2 ENZYME n addmsg /kinetics/PLA2/PLA2 /kinetics/MAPK/MAPK-PP/MAPK_phos_PLA2 SUBSTRATE n addmsg /kinetics/MAPK/PP2A/PP2A_deph_MEK-P /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A/PP2A_deph_MEK-PP /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A/PP2A_deph_AMPAR /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A/PP2A_deph_Raf-P /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/PP2A_deph_MEK-PP ENZYME n addmsg /kinetics/MAPK/MEK-PP /kinetics/MAPK/PP2A/PP2A_deph_MEK-PP SUBSTRATE n addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/PP2A_deph_MEK-P ENZYME n addmsg /kinetics/MAPK/MEK-P /kinetics/MAPK/PP2A/PP2A_deph_MEK-P SUBSTRATE n addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/PP2A_deph_AMPAR ENZYME n addmsg /kinetics/AMPAR/AMPAR-P /kinetics/MAPK/PP2A/PP2A_deph_AMPAR SUBSTRATE n addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/PP2A_deph_Raf-P ENZYME n addmsg /kinetics/MAPK/Raf-P /kinetics/MAPK/PP2A/PP2A_deph_Raf-P SUBSTRATE n addmsg /kinetics/PLA2/PLA2_bind_Ca /kinetics/PLA2/PLA2 REAC A B addmsg /kinetics/PLA2/PLA2-P_deg /kinetics/PLA2/PLA2 REAC B A addmsg /kinetics/MAPK/MAPK-PP/MAPK_phos_PLA2 /kinetics/PLA2/PLA2 REAC sA B addmsg /kinetics/PLA2/PLA2_bind_PIP2 /kinetics/PLA2/PLA2 REAC A B addmsg /kinetics/PLA2/PLA2_bind_Ca /kinetics/PLA2/PLA2-Ca REAC B A addmsg /kinetics/PLA2/PLA2-Ca/PLA2-Ca_prd_AA /kinetics/PLA2/PLA2-Ca REAC eA B addmsg /kinetics/PLA2/PLA2-Ca_bind_PIP2 /kinetics/PLA2/PLA2-Ca REAC A B addmsg /kinetics/PLA2/PLA2-Ca /kinetics/PLA2/PLA2-Ca/PLA2-Ca_prd_AA ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2-Ca/PLA2-Ca_prd_AA SUBSTRATE n addmsg /kinetics/PLA2/PLA2 /kinetics/PLA2/PLA2_bind_Ca SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca /kinetics/PLA2/PLA2_bind_Ca PRODUCT n addmsg /kinetics/PLA2/Ca /kinetics/PLA2/PLA2_bind_Ca SUBSTRATE n addmsg /kinetics/PLA2/PLA2-P_deg /kinetics/PLA2/PLA2-P REAC A B addmsg /kinetics/MAPK/MAPK-PP/MAPK_phos_PLA2 /kinetics/PLA2/PLA2-P MM_PRD pA addmsg /kinetics/PLA2/PLA2-P/PLA2-P_prd_AA /kinetics/PLA2/PLA2-P REAC eA B addmsg /kinetics/PLA2/PLA2-P /kinetics/PLA2/PLA2-P/PLA2-P_prd_AA ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2-P/PLA2-P_prd_AA SUBSTRATE n addmsg /kinetics/PLA2/AA_deg /kinetics/PLA2/APC REAC B A addmsg /kinetics/PLA2/PLA2-PIP2-Ca/PLA2-PIP2-Ca_prd_AA /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PLA2-P/PLA2-P_prd_AA /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PLA2-PIP2/PLA2-PIP2_prd_AA /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PLA2-Ca/PLA2-Ca_prd_AA /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/APC /kinetics/PLA2/AA_deg PRODUCT n addmsg /kinetics/PLA2/AA /kinetics/PLA2/AA_deg SUBSTRATE n addmsg /kinetics/PLA2/PLA2-P /kinetics/PLA2/PLA2-P_deg SUBSTRATE n addmsg /kinetics/PLA2/PLA2 /kinetics/PLA2/PLA2-P_deg PRODUCT n addmsg /kinetics/PLA2/PLA2_bind_PIP2 /kinetics/PLA2/PIP2 REAC A B addmsg /kinetics/PLA2/PLA2-Ca_bind_PIP2 /kinetics/PLA2/PIP2 REAC A B addmsg /kinetics/PLA2/AA_deg /kinetics/PLA2/AA REAC A B addmsg /kinetics/PKC/PKC_bind_AA /kinetics/PLA2/AA REAC A B addmsg /kinetics/PLA2/PLA2-PIP2-Ca/PLA2-PIP2-Ca_prd_AA /kinetics/PLA2/AA MM_PRD pA addmsg /kinetics/PLA2/PLA2-P/PLA2-P_prd_AA /kinetics/PLA2/AA MM_PRD pA addmsg /kinetics/PLA2/PLA2-PIP2/PLA2-PIP2_prd_AA /kinetics/PLA2/AA MM_PRD pA addmsg /kinetics/PLA2/PLA2-Ca/PLA2-Ca_prd_AA /kinetics/PLA2/AA MM_PRD pA addmsg /kinetics/PKC/PKC-Ca_bind_AA /kinetics/PLA2/AA REAC A B addmsg /kinetics/PLA2/PLA2_bind_Ca /kinetics/PLA2/Ca REAC A B addmsg /kinetics/CaInput /kinetics/PLA2/Ca SUMTOTAL n nInit addmsg /kinetics/PLA2/PLA2-PIP2_bind_Ca /kinetics/PLA2/Ca REAC A B addmsg /kinetics/PLA2/PIP2 /kinetics/PLA2/PLA2_bind_PIP2 SUBSTRATE n addmsg /kinetics/PLA2/PLA2 /kinetics/PLA2/PLA2_bind_PIP2 SUBSTRATE n addmsg /kinetics/PLA2/PLA2-PIP2 /kinetics/PLA2/PLA2_bind_PIP2 PRODUCT n addmsg /kinetics/PLA2/PLA2_bind_PIP2 /kinetics/PLA2/PLA2-PIP2 REAC B A addmsg /kinetics/PLA2/PLA2-PIP2_bind_Ca /kinetics/PLA2/PLA2-PIP2 REAC A B addmsg /kinetics/PLA2/PLA2-PIP2/PLA2-PIP2_prd_AA /kinetics/PLA2/PLA2-PIP2 REAC eA B addmsg /kinetics/PLA2/PLA2-PIP2 /kinetics/PLA2/PLA2-PIP2/PLA2-PIP2_prd_AA ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2-PIP2/PLA2-PIP2_prd_AA SUBSTRATE n addmsg /kinetics/PLA2/PLA2-PIP2-Ca/PLA2-PIP2-Ca_prd_AA /kinetics/PLA2/PLA2-PIP2-Ca REAC eA B addmsg /kinetics/PLA2/PLA2-Ca_bind_PIP2 /kinetics/PLA2/PLA2-PIP2-Ca REAC B A addmsg /kinetics/PLA2/PLA2-PIP2_bind_Ca /kinetics/PLA2/PLA2-PIP2-Ca REAC B A addmsg /kinetics/PLA2/PLA2-PIP2-Ca /kinetics/PLA2/PLA2-PIP2-Ca/PLA2-PIP2-Ca_prd_AA ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2-PIP2-Ca/PLA2-PIP2-Ca_prd_AA SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca /kinetics/PLA2/PLA2-Ca_bind_PIP2 SUBSTRATE n addmsg /kinetics/PLA2/PIP2 /kinetics/PLA2/PLA2-Ca_bind_PIP2 SUBSTRATE n addmsg /kinetics/PLA2/PLA2-PIP2-Ca /kinetics/PLA2/PLA2-Ca_bind_PIP2 PRODUCT n addmsg /kinetics/PLA2/Ca /kinetics/PLA2/PLA2-PIP2_bind_Ca SUBSTRATE n addmsg /kinetics/PLA2/PLA2-PIP2 /kinetics/PLA2/PLA2-PIP2_bind_Ca SUBSTRATE n addmsg /kinetics/PLA2/PLA2-PIP2-Ca /kinetics/PLA2/PLA2-PIP2_bind_Ca PRODUCT n addmsg /kinetics/PKC/PKC_bind_Ca /kinetics/PKC/PKC REAC A B addmsg /kinetics/PKC/PKC_bind_AA /kinetics/PKC/PKC REAC A B addmsg /kinetics/PKC/PKC /kinetics/PKC/PKC_bind_Ca SUBSTRATE n addmsg /kinetics/PKC/Ca /kinetics/PKC/PKC_bind_Ca SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca_cyto /kinetics/PKC/PKC_bind_Ca PRODUCT n addmsg /kinetics/PKC/Ca /kinetics/PKC/PKC_bind_Ca SUBSTRATE n addmsg /kinetics/PKC/PKC /kinetics/PKC/PKC_bind_AA SUBSTRATE n addmsg /kinetics/PLA2/AA /kinetics/PKC/PKC_bind_AA SUBSTRATE n addmsg /kinetics/PKC/PKC-AA /kinetics/PKC/PKC_bind_AA PRODUCT n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC_active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-AA /kinetics/PKC/PKC_active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC_active/PKC_phos_AMPAR /kinetics/PKC/PKC_active REAC eA B addmsg /kinetics/PKC/PKC_active/PKC_phos_Raf /kinetics/PKC/PKC_active REAC eA B addmsg /kinetics/PKC/PKC-Ca-AA /kinetics/PKC/PKC_active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC_active /kinetics/PKC/PKC_active/PKC_phos_AMPAR ENZYME n addmsg /kinetics/AMPAR/AMPAR /kinetics/PKC/PKC_active/PKC_phos_AMPAR SUBSTRATE n addmsg /kinetics/PKC/PKC_active /kinetics/PKC/PKC_active/PKC_phos_Raf ENZYME n addmsg /kinetics/MAPK/Raf /kinetics/PKC/PKC_active/PKC_phos_Raf SUBSTRATE n addmsg /kinetics/PLA2/AA /kinetics/PKC/PKC-Ca_bind_AA SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca_bind_AA SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-AA /kinetics/PKC/PKC-Ca_bind_AA PRODUCT n addmsg /kinetics/PKC/PKC-Ca_bind_AA /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca_memb /kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/PKC/PKC-Ca_deg /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca-AA_deg /kinetics/PKC/PKC-Ca-AA REAC A B addmsg /kinetics/PKC/PKC-Ca_bind_AA /kinetics/PKC/PKC-Ca-AA REAC B A addmsg /kinetics/PKC/PKC-AA_bind_Ca /kinetics/PKC/PKC-Ca-AA REAC B A addmsg /kinetics/PKC/PKC-AA_bind_Ca /kinetics/PKC/PKC-AA REAC A B addmsg /kinetics/PKC/PKC-AA_deg /kinetics/PKC/PKC-AA REAC A B addmsg /kinetics/PKC/PKC_bind_AA /kinetics/PKC/PKC-AA REAC B A addmsg /kinetics/PKC/Ca /kinetics/PKC/PKC-AA_bind_Ca SUBSTRATE n addmsg /kinetics/PKC/PKC-AA /kinetics/PKC/PKC-AA_bind_Ca SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-AA /kinetics/PKC/PKC-AA_bind_Ca PRODUCT n addmsg /kinetics/PKC/Ca /kinetics/PKC/PKC-AA_bind_Ca SUBSTRATE n addmsg /kinetics/PKC/PKC_bind_Ca /kinetics/PKC/Ca REAC A B addmsg /kinetics/CaInput /kinetics/PKC/Ca SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-AA_bind_Ca /kinetics/PKC/Ca REAC A B addmsg /kinetics/PKC/PKC_bind_Ca /kinetics/PKC/Ca REAC A B addmsg /kinetics/PKC/PKC-AA_bind_Ca /kinetics/PKC/Ca REAC A B addmsg /kinetics/PKC/PKC-Ca_deg /kinetics/PKC/PKC_deg REAC B A addmsg /kinetics/PKC/PKC-AA_deg /kinetics/PKC/PKC_deg REAC B A addmsg /kinetics/PKC/PKC-Ca-AA_deg /kinetics/PKC/PKC_deg REAC B A addmsg /kinetics/PKC/PKC_deg /kinetics/PKC/PKC-Ca_deg PRODUCT n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca_deg SUBSTRATE n addmsg /kinetics/PKC/PKC-AA /kinetics/PKC/PKC-AA_deg SUBSTRATE n addmsg /kinetics/PKC/PKC_deg /kinetics/PKC/PKC-AA_deg PRODUCT n addmsg /kinetics/PKC/PKC-Ca-AA /kinetics/PKC/PKC-Ca-AA_deg SUBSTRATE n addmsg /kinetics/PKC/PKC_deg /kinetics/PKC/PKC-Ca-AA_deg PRODUCT n addmsg /kinetics/PKC/PKC_bind_Ca /kinetics/PKC/PKC-Ca_cyto REAC B A addmsg /kinetics/PKC/PKC-Ca_memb /kinetics/PKC/PKC-Ca_cyto REAC A B addmsg /kinetics/PKC/PKC-Ca_cyto /kinetics/PKC/PKC-Ca_memb SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca_memb PRODUCT n addmsg /kinetics/PKC/PKC_active/PKC_phos_AMPAR /kinetics/AMPAR/AMPAR-P MM_PRD pA addmsg /kinetics/MAPK/PP2A/PP2A_deph_AMPAR /kinetics/AMPAR/AMPAR-P REAC sA B addmsg /kinetics/PKC/PKC_active/PKC_phos_AMPAR /kinetics/AMPAR/AMPAR REAC sA B addmsg /kinetics/MAPK/PP2A/PP2A_deph_AMPAR /kinetics/AMPAR/AMPAR MM_PRD pA addmsg /kinetics/ramp /kinetics/CaInput REAC B A addmsg /kinetics/ramp /kinetics/CaSource REAC A B addmsg /kinetics/CaSource /kinetics/ramp SUBSTRATE n addmsg /kinetics/CaInput /kinetics/ramp PRODUCT n addmsg /kinetics/CaInput /graphs/conc1/CaInput.Co PLOT Co *CaInput.Co *orange addmsg /kinetics/PLA2/AA /graphs/conc1/AA.Co PLOT Co *AA.Co *violet addmsg /kinetics/AMPAR/AMPAR /graphs/conc2/AMPAR.Co PLOT Co *AMPAR.Co *green addmsg /kinetics/AMPAR/AMPAR-P /graphs/conc2/AMPAR-P.Co PLOT Co *AMPAR-P.Co *yellow addmsg /kinetics/PKC/PKC-Ca /moregraphs/conc3/PKC-Ca.Co PLOT Co *PKC-Ca.Co *orange addmsg /kinetics/PKC/PKC-AA /moregraphs/conc3/PKC-AA.Co PLOT Co *PKC-AA.Co *pink addmsg /kinetics/PKC/PKC-Ca-AA /moregraphs/conc3/PKC-Ca-AA.Co PLOT Co *PKC-Ca-AA.Co *magenta addmsg /kinetics/PKC/PKC_active /moregraphs/conc3/PKC_active.Co PLOT Co *PKC_active.Co *cyan addmsg /kinetics/PKC/PKC_deg /moregraphs/conc3/PKC_deg.Co PLOT Co *PKC_deg.Co *maroon addmsg /kinetics/PKC/PKC-Ca_cyto /moregraphs/conc3/PKC-Ca_cyto.Co PLOT Co *PKC-Ca_cyto.Co *red addmsg /kinetics/MAPK/Raf-P /moregraphs/conc4/Raf-P.Co PLOT Co *Raf-P.Co *#ffff00 addmsg /kinetics/MAPK/MEK-PP /moregraphs/conc4/MEK-PP.Co PLOT Co *MEK-PP.Co *#ffdf00 addmsg /kinetics/MAPK/MAPK-PP /moregraphs/conc4/MAPK-PP.Co PLOT Co *MAPK-PP.Co *#ff4400 addmsg /kinetics/PLA2/PLA2-P /moregraphs/conc4/PLA2-P.Co PLOT Co *PLA2-P.Co *red enddump // End of dump call /kinetics/MAPK/PP2A/notes LOAD \ "0.05 -> 0.04 -> 0.045" call /kinetics/PLA2/PLA2/notes LOAD \ "85-kDa cytosolic phospholipase A2, cPLA2." call /kinetics/PLA2/PLA2_bind_Ca/notes LOAD \ "Gijon et al., (1999) JCB vol.145 pp.1219-1232 Fig.8B" \ "K1/2 = 0.5 uM." \ "" \ "Back to Kuroda et al." call /kinetics/PLA2/AA_deg/notes LOAD \ "0.001 -> 0.006 -> 0.002 -> 0.01" \ "" \ "Back to Kuroda..." call /kinetics/PLA2/PLA2-PIP2/notes LOAD \ "85-kDa cytosolic phospholipase A2, cPLA2." call /kinetics/PKC/PKC_bind_Ca/notes LOAD \ "kf = 0.013 -> 0.0013 -> 0.00013 -> 0.00026 -> 0.00052 -> 0.0004 -> 0.00036" \ "kb = 0.13 -> 0.26 -> 0.52 -> 0.13" \ "" \ "Back to Kuroda..." \ "" \ "kf = 0.013 -> 0.013" \ "kb = 0.13 -> 0.13" call /kinetics/PKC/PKC_bind_AA/notes LOAD \ "In Upi, kf = 0.00012 and kb = 0.1" \ "" call /kinetics/PKC/PKC_active/PKC_phos_AMPAR/notes LOAD \ "1.5 -> 0.0335 -> 0.1 in k4." call /kinetics/PKC/PKC-Ca_bind_AA/notes LOAD \ "In Upi, kf = 0.00012 and kb = 0.1" \ "" call /kinetics/PKC/PKC-AA_bind_Ca/notes LOAD \ "Back to Kuroda..." \ "" call /kinetics/PKC/PKC-Ca_deg/notes LOAD \ "0.004 in Kuroda" call /kinetics/PKC/PKC-AA_deg/notes LOAD \ "0.004 in Kuroda" call /kinetics/PKC/PKC-Ca-AA_deg/notes LOAD \ "0.004 in Kuroda" \ "" call /kinetics/PKC/PKC-Ca_memb/notes LOAD \ "translocation." \ "kf = 1 -> 10 -> 1" \ "kb = 0.1 -> 0.1 -> 0.1" complete_loading