Systems Biology of Cerebellar Purkinje Cells

Ca2+-LTD model
This Ca2+ model quantatively reproduces the relationship of caged-Ca2+ photolysis and cerebellar LTD induction. Used in ‘Ca2+ requirements for cerebellar long-term synaptic depression: role for a postsynaptic leaky integrator. ‘ Tanaka et al., Neuron, if accepted.
This Ca2+ model detects the temporal order of synaptic inputs from parallel and climbing fibers. The model coherently explains varoius LTD experiments derived from different Ca2+ dynamics in simulation results. Used in ‘Inositol 1,4,5-Trisphosphatate-Dependent Ca2+ Therehosld Dynamics Detect Spike Timing in Cerebellar Purkinje Cells. ‘ Doi et al., J Neurosci (2005) 25, 950-961.
Used in ‘Exploration of signal transduction pathways in cerebellar long-term depression by kinetic simulation. ‘ Kuroda et al. J Neurosci 21, 5693-702. The authors have revealed that AMPA receptor phosphorylation is regulated by the linear cascades of PKC in the initial phase and by the MAP kinase-mediated positive feedback loop pathway in the intermediate phase.

Neuro Imaging Data Archives

Block diagram of signaling pathways for cerebellar LTD Data Archives


Neuro Imaging Data Analysis

VBMEG-intro MEG/EEG source estimation using MRI/fMRI information


Multi color software